(S)-(–)-2,3-Methyl­enedi­oxy-8-oxoberbine

In the title optically active protoberberine derivative, C₁₈H₁₅NO₃, the absolute configuration has been confirmed as 13aS. The H atom at the asymmetric centre assumes an α orientation and occupies a bis­ectional position relative to the tetra­hydro­pyridine ring, and is axial to the tetra­hydro­pyridinone ring.

(R)-(+)-3-Chlor-1-(4-morpholino-5-nitro-1H-imidazol-1-yl)propan-2-ol

The absolute configuration of the optically active title compound, (+)-3-chloro-1-(4-morpholino-5-nitro­imidazol-1-yl)­propan-2-ol, C₁₀H₁₅ClN₄O₄, has been confirmed as 2R by structure refinement using Friedel-pair reflections. The nitro group takes part in the conjugation system of the imidazole ring. In consequence, the exocyclic C—N bond is significantly shorter than the normal single Csp²—NO₂ bond. In the crystal structure, the mol­ecules are linked by O—H...N and C—H...O intermolecular hydrogen bonds into an infinite three-dimensional network.

(R)-(+)-2,3-Methyl­enedi­oxy-8-oxoberbine

The title compound [systematic name: (R)-(+)-2,3-methyl­ene­di­oxy-5,6,13,13a-tetra­hydro-8H-dibenzo[a,g]quinolizin-8-one], C₁₈H₁₅NO₃, an optically active protoberberine derivative, was synthesized and its absolute configuration has been additionally confirmed by this crystal structure refinement. The H atom at the asymmetric centre assumes a β configuration and is oriented in the bis­ectional position relative to the tetra­hydro­pyridine ring and axial to the tetra­hydro­pyridinone ring.

(S)-(-)-3-Chlor-1-(4-morpholino-5-nitro-1H-imidazol-1-yl)­propan-2-ol

The optically active title morpholino­nitro­imidazole derivative, C₁₀H₁₅ClN₄O₄, was synthesized and the absolute configuration has been determined as S.