Bis[1-meth­oxy-2,2,2-tris­(pyrazol-1-yl-κN²)ethane]­nickel(II) bis­(tri­fluoro­methane­sulfonate) dihydrate

In the title salt, [Ni(C₁₂H₁₄N₆O)₂](CF₃SO₃)₂·2H₂O, the Ni^II cation is located on an inversion centre and is coordinated by six N atoms from two tridentate 1-meth­oxy-2,2,2-tris­(pyrazol-1-yl)ethane ligands in a distorted octa­hedral geometry. The Ni—N distances range from 2.0594 (12) to 2.0664 (12) Å, intra-ligand N—Ni—N angles range from 84.59 (5) to 86.06 (5)°, and adjacent inter-ligand N—Ni—N angles range between 93.94 (5) and 95.41 (5)°. In the crystal, inversion-related pyrazole rings are π–π stacked, with an inter­planar spacing of 3.4494 (18) Å, forming chains that propagate parallel to the a-axis direction. Inter­molecular O—H...O hydrogen bonds are present between water mol­ecules and tri­fluoro­methane­sulfonate anions.

Bis[1-meth­oxy-2,2,2-tris­(pyrazol-1-yl-κN²)ethane]­nickel(II) bis­(tri­fluoro­methane­sulfonate) methanol disolvate

In the title salt, [Ni(C₁₂H₁₄N₆O)₂](CF₃SO₃)₂·2CH₃OH, the Ni^II ion is coordinated by six N atoms from two tridentate 1-meth­oxy-2,2,2-tris­(pyrazol-1-yl)ethane ligands in a distorted octa­hedral geometry. The Ni^II ion is situated on an inversion centre. The Ni—N distances range from 2.0589 (19) to 2.0757 (19) Å, intra-ligand N—Ni—N angles range from 84.50 (8) to 85.15 (8)°, and adjacent inter-ligand N—Ni—N angles range between 94.85 (8) and 95.50 (8)°. In the crystal, O—H...O hydrogen bonds between methanol solvent mol­ecules and tri­fluoro­methane­sulfonate anions are observed.

3,4',5-Trichloro­biphenyl-4-yl 2,2,2-trichloro­ethyl sulfate

Crystals of the title compound, C₁₄H₈Cl₆O₄S, are twinned by inversion, with unequal components [0.85 (3):0.15 (3)]. The asymmetric unit contains two independent mol­ecules that are related by a pseudo-inversion center. The C_ar-O [1.393 (9) and 1.397 (9) Å] and ester S-O bond lengths [1.600 (5) and 1.590 (5) Å] of both mol­ecules are comparable to the structurally related 2,3,5,5-trichloro­biphenyl-4-yl 2,2,2-trichloro­ethyl sulfate. The dihedral angles between the benzene rings in the two mol­ecules are 37.8 (2) and 35.0 (2)°.

5,5'-Dichloro-2,2'-dimeth­oxy­biphen­yl

In the title mol­ecule, C₁₄H₁₂Cl₂O₂, the dihedral angle between the least-square planes of the benzene rings is 62.17 (6)°. Both meth­oxy groups are slightly out of the plane of the benzene rings to which they are attached, making dihedral angles of 4.22 (18) and 18.82 (16)°.

2,2',5',6-Tetra­chloro-4-[(1S)-1-methyl­prop­oxy]biphen­yl

In the title mol­ecule, C₁₆H₁₄Cl₄O, the dihedral angle between the least-square planes of the benzene rings is 84.40 (7)°. No unusual intermolecular interactions are present.

(E)-13-(4-Amino­phen­yl)parthenolide

The title compound, C₂₁H₂₅NO₃ [systematic name: (3aS,9aR,10aR,10bS,E)-3-[(E)-4-(4-amino­benzyl­idene)-6,9a-dimethyl-3a,4,5,8,9,9a,10a,10b-octa­hydro­oxireno[2′,3′:9,10]cyclo­deca­[1,2-b]furan-2(3H)-one] was obtained from the reaction of parthenolide [synonym: 4,5-ep­oxy­germacra-1(10),11(13)-dieno-12,6-lactone] with 4-iodo­aniline under Heck reaction conditions. It was identified as the E-isomer (conformation about the exocyclic methyl­idene C=C bond; the conformation about the C=C bond in the ten-membered ring is also E). The mol­ecule is built up from fused ten-, five- (lactone) and three-membered (epoxide) rings with a 4-amino­phenyl group as a substituent. The ten-membered ring displays an approximate chair–chair conformation, while the lactone ring has an envelope conformation with the C atom bonded to the ring O atom as the flap. The dihedral angle between the benzene ring of the 4-amino­phenyl moiety and the lactone ring mean plane is 23.50 (8)°. In the crystal, mol­ecules are linked via N—H...O hydrogen bonds, between the amine group and the lactone and epoxide ring O atoms, forming chains propagating along the b-axis direction. Adjacent chains are linked via C—H...O inter­actions, forming an undulating two-dimensional network lying parallel to the plane (001). The absolute structure of the mol­ecule in the crystal was confirmed by resonance scattering [Flack parameter = 0.03 (3)].

13-(Imidazol-1-yl)-11,13-di­hydro­melampomagnolide B monohydrate

The title compound, C₁₈H₂₄N₂O₄·H₂O {systematic name: (1aR,7aS,8R,10aS,10bS,E)-5-hy­droxy­methyl-8-[(1H-imidazol-1-yl)meth­yl]-1a-methyl-2,3,6,7,7a,8,10a,10b-octa­hydro­oxireno[2′,3′:9,10]cyclo­deca­[1,2-b]furan-9(1aH)-one monohydrate}, an imidazole derivative of melampomagnolide B was synthesized under Michael addition conditions. The mol­ecule is built up from fused ten-, five- (lactone) and three-membered (epoxide) rings. The inter­nal double bond of the ten-membered ring identifies it as the cis or E isomer. The lactone ring has an envelope-type conformation, with the (chiral) C atom opposite the lactone O atoms as the flap atom. In the crystal, O—H...O, O—H...N and weak C—H...O hydrogen bonds link the mol­ecules (along with water) into sheets parallel to the bc plane.

13-(N,N-Di­methyl­amino)­micheliolide 0.08-hydrate

The title compound, C₁₇H₂₇NO₃·0.08H₂O {sytematic name: (3R,3aS,9R,9aS,9bS)-3-[(di­methyl­amino)­meth­yl]-9-hy­droxy-6,9-dimethyl-3,3a,4,5,7,8,9,9a-octa­hydro­azuleno[4,5-b]furan-2(9bH)-one 0.08-hydrate}, exhibits intra­molecular O—H...O hydrogen bonding to form a ring of graph-set motif S(6). As well as this intra­molecular hydrogen bond with the lactone-ring O atom, the hy­droxy H atom forms an O—H...O hydrogen bond to the low-occupancy partial water mol­ecule [occupancy = 0.078 (2)]. The water mol­ecule is correlated with disorder of the N(CH₃)₂ group [major–minor occupancy factors are 0.922 (2):0.078 (2)]. The dihedral angle between the mean planes of the trans-fused seven-membered ring and the lactone ring is 4.42 (9)°.