Bosentan monohydrate

In the title compound, C₂₇H₂₉N₅O₆S·H₂O {systematic name: 4-tert-butyl-N-[6-(2-hy­droxy­eth­oxy)-5-(2-meth­oxy­phen­oxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide monohydrate], the dihedral angle between the mean planes of the pyrimidine rings is 27.0 (1)°. The dihedral angle between the mean planes of the benzene rings is 47.7 (8)°, forming a U-shaped channel around the chain of twisted pyrimidine rings. The crystal packing is stabilized by O—H...O, O—H...N and N—H...O hydrogen bonds with a single water mol­ecule, and weak O—H...N inter­molecular inter­actions between the hy­droxy group and one of the pyrimidine rings producing an two-dimensional supra­molecular array in the bc plane. The title compound studied was a merohedral twin with the major component being approximately 57%.

Diphenyl­methyl benzoate

In the title mol­ecule, C₂₀H₁₆O₂, the dihedral angle between the phenyl rings of the diphenyl­methyl group is 68.3 (2)°. The benzoate group is essentially planar, with a maximum deviation of 0.017 (2) Å for the carbonyl O atom, and the two phenyl rings are twisted by 27.5 (4) and 85.6 (9)° from this plane. In the crystal, weak C—H...O hydrogen bonds link mol­ecules along [100].

Olanzapinium dipicrate

The asymmetric unit of the title salt [systematic name: 2-methyl-4-(4-methyl­piperazin-4-ium-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepinium bis­(2,4,6-trinitro­phenolate)], C₁₇H₂₂N₄S²⁺·2C₆H₂N₃O₇⁻, consists of a diprotonated olanzapinium cation and two independent picrate anions. In the cation, the piperazine ring adopts a distorted chair conformation and contains a positively charged N atom with quaternary character and the N atom in the seven-membered 1,5-diazepine ring, which adopts a boat configuration, is also protonated. The dihedral angle between the benzene and thiene rings flanking the diazepine ring is 58.8 (1)°. In one of the picrate anions, a nitro group is disordered over two sets of sites in a 0.748 (5):0.252 (5) ratio, and the benzene ring has a flat envelope conformation with the O⁻ C atom displaced from the mean plane of the other five C atoms [maximum deviation 0.0151 (14) Å] by 0.1449 (14) Å. In the crystal, N—H...O hydrogen bonds and weak inter­molecular C—H...S and C—H...O inter­actions link the components, forming a three-dimensional network.

Orphenadrinium dihydrogen citrate

In the title salt, C₁₈H₂₄NO⁺·C₆H₇O₇⁻, the dihedral angle between the benzene rings in the cation is 74.2 (5)°. In the crystal, anion–anion O—H...O hydrogen bonds and weak O—H...O inter­actions form infinite chains along [100]. Between these chains, cation–anion N—H—O hydrogen bonds are observed, forming an alternate pattern of cation and anion layers and leading to a two-dimensional network parallel to (100).

Ethyl 6-(6-meth­oxy­naphthalen-2-yl)-4-(naphthalen-2-yl)-2-oxocyclo­hex-3-ene-1-carboxyl­ate

The title compound, C₃₀H₂₆O₄, contains an oxo-cyclo­hexane ring in a distorted half-chair configuration, with disorder of two C atoms in a 0.859 (4):0.141 (4) ratio. The dihedral angle between the mean planes of the two napthalene ring systems is 58.6 (8)°.

(E)-N'-(4-Fluoro­benzyl­idene)-2-(3-methyl­phen­yl)acetohydrazide

In the title compound, C₁₆H₁₅FN₂O, the dihedral angles between the benzene rings are74.7(8), 74.1 (1), 74.2 (7) and 74.3 (5)° in the four independent mol­ecules in the asymmetric unit. In the crystal, N-H-O hydrogen bonds involving the hydrazide and acetyl groups, which form R₂²(18) ring motifs, link the mol­ecules into dimers, which form columns along [010].

(2E)-1-(4-Chloro­phen­yl)-3-(4-nitro­phen­yl)prop-2-en-1-one

In the title compound, C₁₅H₁₀ClNO₃, a substituted chalcone, the dihedral angle between the benzene rings is 5.1 (7)°. The nitro group makes a dihedral angle of 12.5 (3)° with the benzene ring to which it is attached. In the crystal, weak C—H...O inter­actions link the mol­ecules into a one-dimensional array along [010]. The crystal studied was an inversion twin, with a refined ratio for the twin components of 0.6060 (9):0.3939 (1).

2-(4-Bromo­phen­yl)-N-(3,4-di­fluoro­phen­yl)acetamide

In the title compound, C₁₄H₁₀BrF₂NO, the dihedral angle between the mean planes of the 4-bromo­phenyl and 3,4-di­fluoro­phenyl rings is 66.4 (1)°. These two planes are twisted by 40.0 (5) and 86.3 (2)°, respectively, from that of the acetamide group. In the crystal, N—H...O hydrogen bonds and weak C—H...O and C—H...F inter­actions form infinite chains along [100].

2-(4-Chloro­phen­yl)-N-(3,4-di­fluoro­phen­yl)acetamide

In the title compound, C₁₄H₁₀ClF₂NO, the dihedral angle between the mean planes of the 4-chloro­phenyl and 3,4-di­fluoro­phenyl rings is 65.2 (1)°. These two planes are twisted by 83.5 (5) and 38.9 (9)°, respectively, from that of the acetamide group. In the crystal, N—H...O hydrogen bonds form infinite chains along [100]. Weak C—H...O and C—H...F inter­actions are also observed and stack mol­ecules along the b axis.