Bosentan monohydrate

In the title compound, C₂₇H₂₉N₅O₆S·H₂O {systematic name: 4-tert-butyl-N-[6-(2-hy­droxy­eth­oxy)-5-(2-meth­oxy­phen­oxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide monohydrate], the dihedral angle between the mean planes of the pyrimidine rings is 27.0 (1)°. The dihedral angle between the mean planes of the benzene rings is 47.7 (8)°, forming a U-shaped channel around the chain of twisted pyrimidine rings. The crystal packing is stabilized by O—H...O, O—H...N and N—H...O hydrogen bonds with a single water mol­ecule, and weak O—H...N inter­molecular inter­actions between the hy­droxy group and one of the pyrimidine rings producing an two-dimensional supra­molecular array in the bc plane. The title compound studied was a merohedral twin with the major component being approximately 57%.

4-(4-Iodo­anilino)-2-methyl­ene-4-oxo­butanoic acid

In the title compound, C₁₁H₁₀INO₃, an addition product of itaconic acid anhydride and 4-iodo­aniline, the least-squares planes defined by the atoms of the aromatic moiety and the non-H atoms of the carb­oxy­lic acid group enclose an angle of 74.82 (11)°. In the crystal, classical O—H...O hydrogen bonds formed by carb­oxy­lic groups, as well as N—H...O hydrogen bonds formed by amide groups, are present along with C—H...O contacts. Together, these connect the mol­ecules into dimeric chains along the b-axis direction.

3-Chloro-4-fluoro­anilinium picrate

In the title picrate salt of a dihalogenated aniline derivative, C₆H₆ClF⁺·C₆H₂N₃O₇⁻, the intra­cyclic C—C—C angles in the picrate anion cover a broad range [111.95 (12)–125.38 (13)°], while those in the aromatic cation span a much narrower range [118.25 (14)–122.33 (13)°]. In the crystal, classical N—H...O hydrogen bonds, as well as C—H...O contacts, connect the ions into layers parallel to (001).

4-[Bis(4-fluoro­phen­yl)meth­yl]-1-[(2E)-3-phenyl­prop-2-en-1-yl]piperazin-1-ium 3-carb­oxy­propano­ate

In the title salt, C₂₆H₂₇F₂N₂⁺·C₄H₅O₄⁻, the piperazine N atom bearing the vinylic substituent is protonated. The piperazine ring adopts a chair conformation. In ther crystal, the succinate monoanions are connected via short O—H...O hydrogen bonds between the carb­oxy­lic acid and carboxyl­ate groups into undulating chains extending along [001] and the flunarizinium monocations are attached to these chains via N⁺—H...O⁻ hydrogen bonds. C—H...O inter­actions connect these chains into a three-dimensional network. The shortest centroid–centroid distance of 3.7256 (10) Å was found between one of the fluorinated benzene rings and the non-fluorinated phenyl ring in the neighbouring mol­ecule related by a glide plane.

3,3,3-Trifluoro-2-hydr­oxy-2-(trifluoro­meth­yl)propionic acid

In the title perfluorinated hy­droxy­isobutyric acid derivative, C₄H₂F₆O₃, the mol­ecule shows approximately C_s symmetry. The carb­oxy group is nearly coplanar with the C—OH moiety and the O=C—C—O(H) torsion angle is 5.5 (2)°. An intra­molecular O—H...O hydrogen bond occurs. In the crystal, O—H...O hydrogen bonds connect the mol­ecules into supra­molecular chains along the a-axis direction.

rac-3,3,3-Trifluoro­lactic acid

The title compound (systematic name: rac-3,3,3-trifluoro-2-hy­droxy­propanoic acid), C₃H₃F₃O₃, is a fluorinated derivative of lactic acid. The O=C—C—O(H) torsion angle is 13.26 (15)°. In the crystal, O—H...O hydrogen bonds and C—H...O contacts connect the mol­ecules into sheets perpendicular to the c axis.

2,4-Dichloro­benzyl 2-meth­oxy­benzoate

In the title compound, C₁₅H₁₂Cl₂O₃, the aromatic rings make a dihedral angle of 10.78 (4)°. In the molecule, there is a short C—H...O contact. In the crystal, C—H...O contacts connect the mol­ecules into C(7)C(8) chains along the b axis. The shortest inter­centroid distance between two benzoic acid aromatic systems is 3.7416 (8) Å.

2-(4-Chloro­phen­yl)-2-oxoethyl naphthalene-1-carboxyl­ate

In the title compound, C₁₉H₁₃ClO₃, an ester of 1-naphthoic acid with an aromatic alcohol, the least-squares planes defined by the C atoms of the respective aromatic systems enclose an angle of 77.16 (3)°. In the crystal, C—H...O contacts connect the mol­ecules into undulating sheets parallel to the bc plane.

2-(4-Bromo­phen­yl)-2-oxoethyl naphthalene-1-carboxyl­ate

In the title compound, C₁₉H₁₃BrO₃, an ester of 1-naphthoic acid with an aromatic alcohol, the least-squares planes defined by the C atoms of the respective aromatic systems enclose an angle of 77.20 (5)°. In the crystal, C—H...O contacts connect the mol­ecules into undulating sheets parallel (100).

Bis(pyridin-2-ylmeth­yl)ammonium nitrate

In the title compound, C₁₂H₁₄N₃⁺·NO₃⁻, the mononitrate of protonated bis­(pyridin-2-ylmeth­yl)amine, the least-squares planes defined by the non-H atoms of the two aromatic moieties inter­sect at an angle of 7.91 (6)°. In the crystal, N—H...N, N—H...O and C—H...N hydrogen bonds, as well as C—H...O contacts, connect the entities into a three-dimensional network. The shortest centroid–centroid distance between two aromatic systems is 3.7255 (8) Å and is apparent between the two different aromatic moieties.