organic compounds
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The molecular conformation of the title compound, C41H29ClN4O3S, is stabilized by intramolecular C—HO and C—HCl hydrogen bonds. The thiazole ring adopts an envelope conformation with the N atom as the flap, while the pyrrolidine ring has a twisted conformation on the N—C bond involving the spiro C atom. The β lactam ring makes dihedral angles of 39.74 (15) and 16.21 (16)° with the mean planes of the thiazole and pyrrolidine rings, respectively. The thiazole ring mean plane makes dihedral angles of 23.79 (13) and 70.88 (13) ° with the pyrrolidine and cyclopentane rings, respectively, while the pyrrolidine ring makes a dihedral angle of 85.63 (13)° with the cyclopentane ring. The O atom attached to the β lactam ring deviates from its mean plane by 0.040 (2) Å, while the O atom attached to the cyclopentane ring deviates from its mean plane by 0.132 (2) Å. In the crystal, molecules are linked by C—HO hydrogen bonds, forming chains along [010], and C—Hπ and π-π interactions [centroid-centroid distance = 3.6928 (17) Å].
organic compounds
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In the title compound, C21H23NO3S, both the thiazole and oxazolidine rings adopt twist conformations. The mean plane of the thiazole ring makes a dihedral angle of 61.02 (7)° with the oxazolidine ring mean plane, and dihedral angles of 22.72 (6) and 75.07 (6)° with the benzene rings. The benzene rings are almost perpendicular to one another, making a dihedral angle of 89.14 (6)°. There are bifurcated intramolecular C—HO hydrogen bonds in the molecular structure. In the crystal, molecules are linked via C—Hπ interactions, forming chains propagating along [100].
organic compounds
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In the title compound, C19H19NO3S, the thiazole and oxazolidine rings each adopt an envelope conformation, with the S and O atoms as the respective flap atoms. The thiazole and oxazolidine rings (all atoms) make a dihedral angle of 66.39 (11)° while the phenyl rings subtend a dihedral angle of 22.71 (10)°.
organic compounds
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In the title compound, C28H25N3O4, the central pyrrolidine ring adopts adopts an envelope conformation with the N atom as the flap and the piperidine ring adopts a chair conformation. The pendant pyrrolidine ring is almost planar (r.m.s. deviation = 0.008 Å). An intramolecular C—HO interaction closes an S(6) ring. In the crystal, inversion dimers linked by pairs of N—HO hydrogen bonds generate R22(8) loops.
organic compounds
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In the title compound, C29H23N3O4, the 2-methylpyrrolidine ring adopts a twist conformation on the N—C bond involving the spiro C atom, while the hydropyran ring adopts an envelope conformation with the methine C atom bonded to the O atom as the flap. The mean plane of the indoline-2-one ring system is almost perpendicular to the mean plane of the pyrrolidine ring, making a dihedral angle of 89.73 (8)°. The latter ring makes dihedral angles of 47.80 (8) with the naphthalene ring system and 32.38 (8)° with the hydropyran ring mean plane. There is an intramolecular C-HO hydrogen bond involving the indoline-2-one O atom. In the crystal, adjacent molecules are linked via N—HO hydrogen bonds, forming chains propagating along [100]. The chains are linked via weak C—HO hydrogen bonds, forming two-dimensional networks, lying parallel to (101), and consolidated by C—Hπ interactions.
organic compounds
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In the title compound, C29H27N3O5, the hydropyran ring adopts an envelope conformation with the methine C atom bearing the para-methoxybenzene ring as the flap. The central pyrrolidine ring has a twist conformation on the N—C bond involving the spiro C atom. The piperidine ring adopts a chair conformation. An intramolecular C—HO contact closes an S(7) ring. In the crystal, inversion dimers linked by C—HO interactions generate R22(18) loops and N—HO hydrogen bonds connect the dimers into [100] chains.