(1S,3′S,3a′R,6′S)-6′-(2-Chloro­phen­yl)-3′-[(2R,3S)-1-(4-meth­oxy­phen­yl)-4-oxo-3-phenyl­azetidin-2-yl]-2-oxo-3′,3′a,4′,6′-tetra­hydro-2H,2′H-spiro­[ace­naphthyl­ene-1,1′-pyrrolo­[1,2-c][1,3]thia­zole]-2′,2′-dicarbo­nitrile

The mol­ecular conformation of the title compound, C₄₁H₂₉ClN₄O₃S, is stabilized by intra­molecular C—H...O and C—H...Cl hydrogen bonds. The thia­zole ring adopts an envelope conformation with the N atom as the flap, while the pyrrolidine ring has a twisted conformation on the N—C bond involving the spiro C atom. The β la­ctam ring makes dihedral angles of 39.74 (15) and 16.21 (16)° with the mean planes of the thia­zole and pyrrolidine rings, respectively. The thia­zole ring mean plane makes dihedral angles of 23.79 (13) and 70.88 (13) ° with the pyrrolidine and cyclo­pentane rings, respectively, while the pyrrolidine ring makes a dihedral angle of 85.63 (13)° with the cyclo­pentane ring. The O atom attached to the β la­ctam ring deviates from its mean plane by 0.040 (2) Å, while the O atom attached to the cyclo­pentane ring deviates from its mean plane by 0.132 (2) Å. In the crystal, mol­ecules are linked by C—H...O hydrogen bonds, forming chains along [010], and C—H...π and π-π inter­actions [centroid-centroid distance = 3.6928 (17) Å].

Methyl 3,5-bis­[(3-chloro­pyrazin-2-yl)­oxy]benzoate

In the title compound, C₁₆H₁₀Cl₂N₄O₄, the pyrazine rings make dihedral angles of 67.82 (9) and 75.91 (9)° with the benzene ring, while the dihedral angle between the pyrazine rings is 44.69 (10)°. The meth­oxy­carbonyl group makes a dihedral angle of 16.82 (8)° with the benzene ring to which it is attached. In the crystal, C—H...O hydrogen bonds link the mol­ecules, forming chains running along the ab plane.

3-Hy­droxy-1-[(morpholin-4-yl)meth­yl]pyridazin-6(1H)-one

In the title compound, C₉H₁₃N₃O₃, the morpholine ring adopts a chair conformation and its mean plane makes a dihedral angle of 68.00 (11)° with the pyridazine ring. The carbonyl O atom deviates from the plane of the pyridazine ring by 0.0482 (12) Å. An intra­molecular C—H...O hydrogen bond occurs. In the crystal, mol­ecules are linked by O—H...O and C—H...O hydrogen bonds, forming chains along [1-10].

(Z)-3-(2-Amino­anilino)-1-phenyl­but-2-en-1-one

In the title compound, C₁₆H₁₆N₂O, the phenyl and 2-amino­phenyl rings are almost perpendicular to one another, with a dihedral angle of 82.77 (8)°. There is an intra­molecular N—H...O hydrogen bond in the mol­ecule. In the crystal, mol­ecules are linked via N—H...O hydrogen bonds forming chains along [001]. There are also C—H...π inter­actions present, linking the chains to form a three-dimensional structure.

L-Histidinium p-toluene­sulfonate

In the title salt, C₆H₁₀N₃O₂⁺·C₇H₇O₃S⁻, the imidazole ring makes a dihedral angle of 70.93 (12)° with the plane of the toluene ring. In the crystal, the ions are linked via N—H...O and weak C—H...O hydrogen bonds forming two-dimensional networks lying parallel to (001). These networks are linked via C—H...π inter­actions, forming a three-dimensional structure.

(E)-3-[4-(Di­fluoro­meth­oxy)-3-hy­droxy­phen­yl]-1-phenyl­prop-2-en-1-one

In the title compound, C₁₆H₁₂F₂O₃, the plane of the phenyl ring makes a dihedral angle of 3.22 (8)° with that of the benzene ring. The mol­ecule has an E conformation about the C=C bond. In the crystal, mol­ecules are linked via pairs of O—H...O hydrogen bonds, forming inversion dimers which are further consolidated by a pair of C—H...O hydrogen bonds. The dimers are linked via C—H...O hydrogen bonds, forming columns along the b-axis direction.

8,15-Dioxa-10,13-di­aza­tetra­cyclo­[14.4.0.0^2,7.0^9,14]icosa-1(16),2,4,6,9(14),10,12,17,19-nona­ene

The asymmetric unit of the title compound, C₁₆H₁₀N₂O₂, contains one half-mol­ecule, the complete mol­ecule being generated by twofold rotation symmetry. The plane of the pyrazine ring forms a dihedral angle of 64.87 (6)° with that of the benzene ring, and the planes of the two benzene rings are inclined to one another by 54.20 (6)°. The O atom deviates from the plane of the benzene ring by 0.1549 (8) Å. There are no significant inter­molecular inter­actions in the crystal.

1,3-Bis[(3-chloro­pyrazin-2-yl)­oxy]benzene

The asymmetric unit of the title compound, C₁₄H₈Cl₂N₄O₂, contains one half-mol­ecule, the complete mol­ecule being generated by the operation of a twofold rotation axis. The Cl atom deviates significantly from the plane of the pyrazine ring [0.0215 (4) Å]. The central benzene ring makes a dihedral angle of 72.82 (7)° with the plane of the pyrazine ring.

3-(4-Chloro­phen­yl)-1-cyclo­propyl-2-(2-fluoro­phen­yl)-5-phenyl­pentane-1,5-dione

In the title compound, C₂₆H₂₂ClFO₂, the cyclo­propane ring is disordered over two orientations, with site-occupancy factors of 0.64 (2) and 0.36 (2). The major occupancy component of the cyclo­propane ring makes dihedral angles of 47.6 (7), 50.4 (7) and 65.4 (7)° with the fluoro-, chloro- and unsubstituted benzene rings, respectively [the corresponding values for the minor occupancy component are 47.6 (12), 51.0 (12) and 60.9 (12)°]. An intra­molecular C—H...O hydrogen bond occurs. The F and Cl atoms deviate by 0.0508 (12) and 0.0592 (7) Å from the planes of their attached benzene rings. In the crystal, C—H...F hydrogen bonds link the mol­ecules into chains along the b-axis direction.