(1′S,4′S)-5-(2,5-Dimethyl­phen­yl)-4′-meth­oxy-6-oxa-3-aza­spiro­[bicyclo­[3.1.0]hexane-2,1′-cyclo­hexa­n]-4-one

In the title compound, C₁₈H₂₃NO₃, the cyclo­hexane ring has a chair conformation. The oxirane plane (OCC) makes a dihedral angle of 76.15 (13)° with that of the pyrrolidine ring to which it is fused. The mean plane of the cyclo­hexane ring and the benzene ring are almost normal to the pyrrolidine ring, with dihedral angles of 88.47 (8) and 77.85 (8)°, respectively. In the crystal, mol­ecules are linked via pairs of N—H...O hydrogen bonds, forming inversion dimers. These dimers are linked via pairs of C—H...O hydrogen bonds, forming chains along the a-axis direction.

3-(2,5-Di­methyl­phen­yl)-8-meth­oxy-2-oxo-1-aza­spiro­[4.5]dec-3-en-4-yl 3-(2-bromo-4-fluoro­phen­yl)acrylate

In the title compound, C₂₇H₂₇BrFNO₄, which is an inhibitor of acetyl-CoA carboxyl­ase, the cyclo­hexane ring displays a chair comformation with the spiro-C and meth­oxy-bearing C atoms deviating by 0.681 (7) and −0.655 (1) Å, resppectively, from the mean plane formed by the other four C atoms of the spiro-C₆ ring. The mean planes of the cyclo­hexane and 2-bromo-4-fluoro­phenyl rings are nearly perpendicular to that of the pyrrolidine ring, making dihedral angles 89.75 (6) and 87.60 (9)°, respectively. In the crystal, mol­ecules are linked via pairs of N—H...O hydrogen bonds, forming inversion dimers.