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In the title compound, C26H27ClN3O3P, the mean plane of the central pyrazole ring forms a dihedral angle of 71.37 (14)° with the chloro­phenyl ring. In the crystal, mol­ecules are linked by pairs of N—H...O hydrogen bonds, forming inversion dimers with R22(10) ring motifs. The 3-phenyl ring is disordered with four C atoms occupying two sets of sites with an occupancy ratio of 0.748 (4):0.252 (4).

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In the title compound, C16H13NO2, the isoxazole ring makes dihedral angles of 17.1 (1)° with the 3-meth­oxy­phenyl ring and 15.2 (1)° with the phenyl group. Centrosymmetric dimers that are realised by pairs of C—H...π inter­actions are observed in the crystal structure.

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In the title compound, C16H15BrN2O4, the six-membered carbocyclic ring of the chromene moiety adopts an envelope conformation with the disordered methyl­ene C atom as the flap. The pyran ring is almost orthogonal to the chloro­phenyl ring, making a dihedral angle of 87.11 (12)°. The amine-group N atom deviates significantly from the pyran ring [0.238 (3) Å]. The mol­ecular structure is stabilized by an intra­molecular N—H...O hydrogen bond, which generates an S(6) ring motif. In the crystal, mol­ecules are linked via C—H...O hydrogen bonds, which generate C(8) chains running parallel to the b axis. The chains are linked by C—H...π inter­actions. The methyl­ene-group C atom of the chromene system that is disordered, along with its attached H atoms and the H atoms on the two adjacent C atoms, has an occupancy ratio of 0.791 (7):0.209 (7).

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The title compound, C16H15ClN2O4, contains a chiral centre and crystallizes as a racemate. The methyl­ene group β-positioned to the carbonyl group is partially (21%) disordered. It flips to the opposite sides of the corresponding six-membered carbocycle by −0.304 (3) and 0.197 (11) Å, producing alternative envelope conformations. The planes of the pyran and chloro­phenyl rings form a dihedral angle of 86.25 (9)°. The mol­ecular structure is characterized by an intra­molecular N—H...O inter­action, which generates an S(6) ring motif. The corresponding amino N atom deviates from the plane of the pyran ring by 0.1634 (19) Å. In the crystal, mol­ecules are linked via C—H...O hydrogen bonds, forming C(8) chains running parallel to the b-axis direction. The crystal structure also features C—H...π inter­actions.

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In the title compound, C19H14N2O5, the spiro junction links an oxindole moeity and a furan ring, which subtend a dihedral angle of 83.49 (6)°. The mol­ecular structure features an N—H...O hydrogen bond, which generates an S(6) ring motif. The crystal packing is governed by two N—H...O inter­actions, one of which generates a centrosymmetric R22(14) dimer. The other N—H...O inter­action along with a C—H...O hydrogen bond contributes to the formation of a C22[R22(9)] dimeric chain running along the b-axis direction.

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In the title compound, C31H25N5O3·C2H6OS, the three indole/indoline units are all essentially planar with maximum deviations of 0.0172 (3), 0.053 (2) and 0.07 (2) Å. The pyrrolidine ring adopts an envelope conformation with the C atoms bearing the 1-ethyl-2-oxo­indole substituent (in which the five-membered ring adopts a twisted conformation) as the flap. The dimethyl sulfoxide solvent mol­ecule is disordered over two positions, with an occupancy factor ratio of 0.871 (4):0.129 (4). The solvent components are linked to the heterocyclic mol­ecule via C—H...O and C—H...S hydrogen bonds. In the crystal, the solvent components are linked to the heterocyclic molecule via C—H...O and C—H...S inter­actions, forming R22(10) ring motifs. The mol­ecules are further connected into a chain along the a-axis direction via N—H...O hydrogen bonds.

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The title compound, C16H15N3O6, is asymmetric with a chiral centre located in the pyran ring and crystallizes as a racemate. The six-membered carbocyclic ring adopts an envelope conformation with the central CH2 C atom as the flap. The amine N atom deviates from the mean plane of the pyran ring by 0.1365 (15) Å. The nitro­phenyl ring is almost orthogonal to the pyran ring and the mean plane of the six-membered carbocyclic ring, the dihedral angle between their mean planes being 88.30 (7) and 87.61 (8)°, respectively. The mol­ecular structure is stabilized by an intra­molecular N—H...O hydrogen bond, which generates an S(6) ring motif. In the crystal, mol­ecules are linked via C—H...O hydrogen bonds, forming infinite bands lying parallel to (-110) and composed of alternate R22(24) and R24(12) graph-set ring motifs. The crystal structure is further stabilized by C—H...π inter­actions, forming a three-dimensional structure.

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In the title compound, C25H20N6O2·0.15H2O, the dihedral angles between the least-squares planes of the indole and pyrrolidine rings and between the oxindole and imidazole rings are 77.66 (7) and 45.31 (7)°, respectively. The pyrrolidine ring and the fused five-membered pyrrolidine ring of the oxindole moiety exhibit twisted conformations. The amide N atom is involved in both intra- and inter­molecular hydrogen bonding, having a bifurcated character. The mol­ecular structure is characterized by an intra­molecular N—H...O hydrogen bond, which generates an S(7) ring motif while an inter­molecular N—H...O hydrogen bond links the organic and solvent water mol­ecules. In the crystal, N—H...N hydrogen bonds generate a zigzag chain running parallel to c-axis direction. The H atoms of the solvent water mol­ecule were not located.

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In the title compound, C26H20N4O2S, the central pyrrolidine ring adopts a twist conformation on the C—C bond involving the spiro C atom. Its mean plane makes dihedral angles of 78.83 (14), 65.91 (15) and 44.49 (18)° with the mean planes of the adjacent oxindole ring system, the indole system and the thio­phene ring, respectively. The indole and indoline units are essentially planar, with maximum deviations of 0.019 (3) and 0.090 (3) Å, respectively. In the oxindole fused-ring system, the pyrrole ring adopts an envelope conformation with the spiro C atom as the flap. In the crystal, pairs of N—H...O hydrogen bonds link the mol­ecules, forming inversion dimers with an R22(8) ring motif. The dimers are linked by further N—H...O hydrogen bonds, forming a two-dimensional network lying parallel to (100).
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