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organic compounds
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The title compound, C37H67NO13·2C2H6OS·1.43H2O, is a macrolide antibiotic with better solubility and better dermal penetration abilities than erythromycin A itself. The asymmetric unit of this form contains one erythromycin A molecule, two dimethyl sulfoxide (DMSO) solvent molecules, a fully occupied water molecule and a partially occupied water molecule with an occupancy factor of 0.432 (11). The 14-membered ring of the erythronolide fragment has a conformation which differs considerably from that in erythromycin A dihydrate [Stephenson, Stowell, Toma, Pfeiffer & Byrn (1997). J. Pharm. Sci. 86, 1239–1244]. One of the two DMSO molecules is disordered over two orientations; the orientation depends on the presence or absence of the second, partially occupied, water molecule. In the crystal, erythromycin molecules are connected by O—H
O hydrogen bonds involving the hydroxy groups and the fully occupied water molecule to form layers parallel to (010). These layers are connected along the b-axis direction only by a possible hydrogen-bonding contact involving the partially occupied water molecule.
O hydrogen bonds involving the hydroxy groups and the fully occupied water molecule to form layers parallel to (010). These layers are connected along the b-axis direction only by a possible hydrogen-bonding contact involving the partially occupied water molecule.organic compoundsOpen access
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The crystal packing of the title compound, C13H19NO·0.33C7H8, shows a channel at [001], which contains grossly disordered toluene solvent molecules. The angle between the benzene ring and the mean plane of the formamide group is 71.1 (1)°. The amide groups of neighbouring molecules are connected by N—HO hydrogen bonds, forming 21 helical chains propagating along [001]. Molecules are also connected by weak intermolecular C—HO hydrogen bonds, forming 61 helices.
O hydrogen bonds, forming 21 helical chains propagating along [001]. Molecules are also connected by weak intermolecular C—HO hydrogen bonds, forming 61 helices.organic compoundsOpen access
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In the title molecule, C18H17N5O2, the dihedral angle between the benzene plane and the benzimidazole plane is 19.8 (1)° and the angle between the benzene plane and the triazole plane is 16.7 (1)°. In the crystal, molecules are connected by O—HN hydrogen bonds, forming zigzag chains along the c-axis direction. The chains are connected by bifurcated N—H(N,N) hydrogen bonds into layers parallel to (100). These layers are connected along the a-axis direction by weak C—HO contacts, forming a three-dimensional network.
N hydrogen bonds, forming zigzag chains along the c-axis direction. The chains are connected by bifurcated N—H(N,N) hydrogen bonds into layers parallel to (100). These layers are connected along the a-axis direction by weak C—HO contacts, forming a three-dimensional network.
