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The mol­ecules of the title compound, C20H15BrClNO, are linked into chains by a C-H...[pi](arene) hydrogen bond, in which the acceptor is the brominated ring of the naphthalene unit, and these chains are linked by an aromatic [pi]-[pi] stacking inter­action, again involving the naphthalene unit, into a sheet structure.

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The closely related compounds cis-(2RS,4SR)-2-(thio­phen-2-yl)-2,3,4,5-tetra­hydro-1H-1-benzazepin-4-ol, C14H15NOS, (I), and cis-(2RS,4SR)-2-(5-methyl­thio­phen-2-yl)-2,3,4,5-tetra­hy­dro-1H-1-benzazepin-4-ol, C15H17NOS, (II), both crystallize with Z' = 2 in the space group P\overline{1}. In (I), the thienyl substituent in one of the two independent mol­ecules is disordered over two sets of atomic sites having occupancies of 0.856 (2) and 0.144 (2). In both compounds, the two independent hy­droxy O atoms are both within 2.8 Å of the hy­droxy O atoms of two neighbouring mol­ecules, and all of the hy­droxy H atoms are disordered, each over two sites. The resulting O-H...O hydrogen bonds generate two similar but distinct C44(8) chains, depending upon which hy­droxy H-atom sites are occupied or vacant, with full correlation of the hy­droxy H-atom occupancies within each chain. Comparisons are made with the supra­molecular assembly in some related compounds.

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The structures are reported of nine closely related tetra­hydro-1,4-ep­oxy-1-benzazepines carrying pendant heterocyclic sub­stituents, namely: 2-exo-(5-nitro­furan-2-yl)-2,3,4,5-tetra­hydro-1,4-ep­oxy-1H-1-benzazepine, C14H12N2O4, (I), 7-fluoro-2-exo-(1-methyl-1H-pyrrol-2-yl)-2,3,4,5-tetra­hydro-1,4-ep­oxy-1H-1-benzazepine, C15H15FN2O, (II), 7-fluoro-2-exo-(5-methyl­furan-2-yl)-2,3,4,5-tetra­hydro-1,4-ep­oxy-1H-1-benzazepine, C15H14FNO2, (III), 7-fluoro-2-exo-(3-methylthio­phen-2-yl)-2,3,4,5-tetra­hydro-1,4-ep­oxy-1H-1-benzazepine, C15H14FNOS, (IV), 7-fluoro-2-exo-(5-methyl­thio­phen-2-yl)-2,3,4,5-tetra­hy­dro-1,4-ep­oxy-1H-1-benzazepine, C15H14FNOS, (V), 7-chloro-2-exo-(5-methyl­furan-2-yl)-2,3,4,5-tetra­hydro-1,4-ep­oxy-1H-1-benzazepine, C15H14ClNO2, (VI), 2-exo-(5-methyl­furan-2-yl)-7-trifluoro­meth­oxy-2,3,4,5-tetrahydro-1,4-ep­oxy-1H-1-benzazepine, C16H14F3NO3, (VII), 2-exo-(3-methyl­thio­phen-2-yl)-7-trifluoro­meth­oxy-2,3,4,5-tetra­hydro-1,4-ep­oxy-1H-1-benzazepine, C16H14F3NO2S, (VIII), and 2-exo-(5-nitro­furan-2-yl)-7-trifluoro­meth­oxy-2,3,4,5-tetra­hydro-1,4-ep­oxy-1H-1-benzazepine, C15H11F3N2O5, (IX). All nine compounds crystallize in centrosymmetric space groups as racemic mixtures with configuration (2RS,4SR). There are no direction-specific inter­actions between the mol­ecules in (V). The mol­ecules in (III), (IV), (VI) and (VII) are linked into simple chains, by means of a single C-H...O hydrogen bond in each of (III), (VI) and (VII), and by means of a single C-H...[pi](arene) hydrogen bond in (IV), while the mol­ecules in (VIII) are linked into a chain of rings. In each of (I) and (II), a combination of one C-H...O hydrogen bond and one C-H...[pi](arene) hydrogen bond links the mol­ecules into sheets, albeit of completely different construction in the two compounds. In (IX), the sheet structure is built from a combination of four independent C-H...O hydrogen bonds and one C-H...[pi](arene) hydrogen bond. Comparisons are made with some related compounds.

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(2RS,4RS)-7-Fluoro-2-(2-phenyl­ethyl)-2,3,4,5-tetra­hydro-1H-1,4-ep­oxy-1-benzazepine, C18H18FNO, (I), and (2RS,4RS)-7-chloro-2-(2-phenyl­ethyl)-2,3,4,5-tetra­hydro-1H-1,4-ep­oxy-1-benzazepine, C18H18ClNO, (II), are isomorphous but not strictly isostructural, as the slight differences in the unit-cell dimensions and mol­ecular conformations are sufficient to preclude, in the structure of (I), the direction-specific inter­molecular inter­actions present in the structure of (II), where the mol­ecules are linked into sheets by a combination of C-H...N and C-H...[pi](arene) hydrogen bonds.

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In both 2-amino-6-meth­oxy-4-(4-methyl­anilino)-5-nitroso­py­rimidine, C12H13N5O2, (I), and ethyl N-[4-(1-adamantylamino)-2-amino-5-nitroso­pyrimidin-6-yl]-3-amino­propionate, C19H28N6O3, (II), the nitroso­pyrimidine unit is planar and the bond distances provide evidence for significant polarization of the electronic structures. In (II), the eth­oxy­carbonyl fragment of the mol­ecule is disordered over two sets of sites with occupancies of 0.910 (4) and 0.090 (4). In the mol­ecules of both compounds, there is an intra­molecular N-H...O hydrogen bond. The mol­ecules of (I) are linked into a chain of rings by a combination of N-H...O and C-H...O hydrogen bonds, while the mol­ecules of (II) are linked by a two-centre N-H...N hydrogen bond and a three-centre N-H...(N,O) hydrogen bond to form sheets containing four distinct types of ring.
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