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LegC3 is an effector secreted by Legionella pneumophila, and is believed to act by inhibiting vacuolar fusion. The function of LegC3 has been shown to be associated primarily with the N-terminal domain, the structure of which has been determined here.

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A case study on the treatment of SIRAS data using the originally unknown protein LegC3N is described. An iterative direct-method-based treatment was proposed that led to improved results in this particular test case.
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