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The polyfluorinated compound 2,2′,3,3′,5,5′,6,6′-octafluoro-4,4′-biphenyldiol (JF0064) is a potent inhibitor (IC50 ≤ 1 µM) of both aldose reductase and AKR1B10. X-ray structures of ternary complexes of both enzymes with JF0064 allow it to be inferred that this lead compound binds to the enzyme active site through an acidic phenol group and allow the extraction of important hints for structure-based drug design.

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