The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure

I. T. N. Campos, T. A. C. B. Souza, R. J. S. Torquato, R. De Marco, A. M. Tanaka-Azevedo, A. S. Tanaka and J. A. R. G. Barbosa

Crystal structures of factor XIIa inhibitor infestin 4 and infestin 1–trypsin complex have been refined at 1.4 and 2.5 Å resolutions, respectively. Mutants of infestin 4 highly specific to factor XIIa were selected by phage display.

Keywords: Triatoma infestans; Kazal-type serine protease inhibitors; blood coagulation; thrombin inhibitors; factor XIIa inhibitors.

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Format		BIBTeX
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