Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362

The soluble extracellular fragment of the interleukin-3 alpha receptor (IL3Rα) was complexed with the Fab fragment of antibody CSL362 and crystals of the IL3Rα–CSL362 complex were obtained. These crystals belonged to the monoclinic P2₁ space group and diffracted to 2.8 Å resolution at the Australian Synchrotron.

Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-β

In order to understand the molecular basis of action of the Alzheimer's disease passive immunotherapy candidate bapineuzumab, the Fab fragment of this antibody was crystallized in complexes with Aβ peptides. The best crystals diffracted to a resolution of 2.0 Å (Aβ residues 1–8) and 2.2 Å (Aβ residues 1–28).