organic compounds
Open access
In the title compound, C31H25N5O3·C2H6OS, the three indole/indoline units are all essentially planar with maximum deviations of 0.0172 (3), 0.053 (2) and 0.07 (2) Å. The pyrrolidine ring adopts an envelope conformation with the C atoms bearing the 1-ethyl-2-oxoindole substituent (in which the five-membered ring adopts a twisted conformation) as the flap. The dimethyl sulfoxide solvent molecule is disordered over two positions, with an occupancy factor ratio of 0.871 (4):0.129 (4). The solvent components are linked to the heterocyclic molecule via C—HO and C—HS hydrogen bonds. In the crystal, the solvent components are linked to the heterocyclic molecule via C—HO and C—HS interactions, forming R22(10) ring motifs. The molecules are further connected into a chain along the a-axis direction via N—HO hydrogen bonds.
organic compounds
Open access
In the title compound, C25H20N6O2·0.15H2O, the dihedral angles between the least-squares planes of the indole and pyrrolidine rings and between the oxindole and imidazole rings are 77.66 (7) and 45.31 (7)°, respectively. The pyrrolidine ring and the fused five-membered pyrrolidine ring of the oxindole moiety exhibit twisted conformations. The amide N atom is involved in both intra- and intermolecular hydrogen bonding, having a bifurcated character. The molecular structure is characterized by an intramolecular N—HO hydrogen bond, which generates an S(7) ring motif while an intermolecular N—HO hydrogen bond links the organic and solvent water molecules. In the crystal, N—HN hydrogen bonds generate a zigzag chain running parallel to c-axis direction. The H atoms of the solvent water molecule were not located.
organic compounds
Open access
In the title compound, C26H20N4O2S, the central pyrrolidine ring adopts a twist conformation on the C—C bond involving the spiro C atom. Its mean plane makes dihedral angles of 78.83 (14), 65.91 (15) and 44.49 (18)° with the mean planes of the adjacent oxindole ring system, the indole system and the thiophene ring, respectively. The indole and indoline units are essentially planar, with maximum deviations of 0.019 (3) and 0.090 (3) Å, respectively. In the oxindole fused-ring system, the pyrrole ring adopts an envelope conformation with the spiro C atom as the flap. In the crystal, pairs of N—HO hydrogen bonds link the molecules, forming inversion dimers with an R22(8) ring motif. The dimers are linked by further N—HO hydrogen bonds, forming a two-dimensional network lying parallel to (100).