Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal

The structures of retinal-bound and retinol-bound hCRBPII are reported. The X-ray flux-dependent and wavelength-dependent rearrangement of retinol in the binding pocket of hCRBPII is demonstrated. The binding modes of retinol and retinal in CRBPI and CRBPII are contrasted.