research papers
The crystal structure of PvuRts1I was determined and a 5-hydroxymethylcytosine-binding pocket was identified in the SRA-like domain. Enzyme variants were engineered to assist in hydroxymethylome mapping based on the crystal structure of PvuRts1I.
research papers
The structures of sperm whale myoglobin variants show that longer distances between the heme axial water and the distal histidine (i.e. weaker hydrogen bonds) correlate with stronger peroxidase activity.
research papers
Although urea and guanidine hydrochloride are commonly used to denature proteins, the molecular underpinnings of this process have remained unclear for a century. To address this question, crystal structures of β-catenin were determined at various urea concentrations.