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In the title compound, C22H17BrN2O4S, the central dihydropyrimidine ring, with a chiral C atom, is significantly puckered and adopts a half-chair conformation with the chiral C atom displaced from the mean plane of the remaining ring atoms by 0.305 (6) Å. The hydroxy-phenyl ring is positioned axially to the pyrimidine ring and almost bisects it, the dihedral angle between the mean-planes of the two rings being 89.78 (12)°. The meth­oxy­carbonyl group is disordered over two sites with an occupancy ratio of 0.568 (5):0.432 (5), resulting in a major and a minor conformer. In the crystal, O—H...N and C—H...S inter­actions result in sheets along the c axis. The supra­molecular assembly is stabilized by π–π stacking inter­actions between the 2-bromo­benzyl­idene and thia­zolopyrimidine rings [centroid–centroid distance = 3.632 (1) Å]. In addition, C—H...π inter­actions are also observed in the crystal structure.

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In the title compound, C17H20N2O4S, the aryl ring is positioned perpendicular to the dihydro­pyrimidine ring, the dihedral angle between the ring planes being 77.48 (9)°. The carboxyl­ate and methyl groups are in a cis conformation with respect to the C=C bond. The dihydro­pyrimidine ring adopts a twist-boat conformation. The crystal structure is stabilized by N—H...O and C—H...O inter­actions, the former resulting in mol­ecular chains along the b axis and the latter forming inversion dimers.

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In the title compound, C7H7ClN4O, the pyrazolo­pyrimidine ring is essentially planar, the r.m.s. deviation of the fitted atoms being 0.0071 Å. The crystal structure features strong N—H...O hydrogen bonds and further consolidated by weak C—H...O, C—H...N and C—H...Cl inter­actions.

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In the title compound, C12H16N4S, the fused benzothio­phene and the pyrimidine rings are coplanar [dihedral angle = 1.61 (6)°]. Three C atoms of the cyclohexene ring (at positions 3, 6 and 7) are disordered over two sites with an occupancy ratio of 0.702 (8):0.298 (8). The cyclo­hexene ring in both the major and minor components adopts a half-chair conformation. The crystal structure is stabilized by N—H...N and C—H...N inter­actions, resulting in the formation of inversion dimers with R22(10) and R22(12) graph-set motifs.

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In the title compound, C20H22N2O4S, the central pyrimidine ring incorporating a chiral C atom is significantly puckered and adopts a slight boat conformation with C atom bearing the phenyl ring and the N atom opposite displaced by 0.367 (2) and 0.107 (2) Å, respectively, from the plane formed by the remaining ring atoms. The benzene ring is positioned axially to the pyrimidine ring, making a dihedral angle of 88.99 (5)°. The thia­zole ring is essentially planar (r.m.s. deviation = 0.0033 Å). In the crystal, pairs of C—H...O inter­actions result in centrosymmetric dimers with graph-set motifs R12(7) and R22(8). A weak C—H...π contact is also observed.

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In the title compound, C10H12N2S, the thio­phene ring is essentially planar (r.m.s. deviation = 0.0290 Å). The two C atoms of the cyclo­hexene ring (at positions 6 and 7) are disordered over two sets of sites in a 0.810 (5):0.190 (5) ratio. The cyclo­hexene rings in both the major and minor occupancy conformers adopt a half-chair conformation. In the crystal, there are two types of N—H...N inter­action. One of these results in centrosymmetric head-to-head dimers corresponding to an R22(12) graph-set motif and the other forms a 20-membered macrocyclic ring involving six mol­ecules.
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