Crystallization and low-resolution structure of an effector-caspase/P35 complex: similarities and differences to an initiator-caspase/P35 complex

Baculovirus P35 is a protein that prevents apoptosis in a diverse range of organisms. P35 stoichiometrically inhibits the apoptotic caspases in a cleavage-dependant mechanism that involves formation of a tight complex. An insect effector-caspase/P35 complex has been crystallized and its low-resolution structure is compared with the human initiator-caspase/P35 structure.