Methyl 2-amino-4-(4-chloro­phenyl)-4H-pyrano[3,2-c]coumarin-3-carboxyl­ate N,N-dimethyl­formamide solvate

The title compound [systematic name: methyl 2-amino-4-(4-chloro­phenyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carb­oxyl­ate N,N-dimethyl­formamide solvate], C₂₀H₁₄ClNO₅·C₃H₇NO, was synthesized by the reaction of 4-hydroxy­coumarin and methyl 4′-chloro-2-cyano­cinnamate catalyzed by KF-montmorillonite. There are N—H...O hydrogen bonds and C—H...O interactions in the crystal structure.

Meth­yl 3-amino-1-(2-chloro­phen­yl)-9-meth­oxy-5,6-dihydro-1H-naphtho[2,1-b]pyran-2-carboxyl­ate

The title compound, C₂₂H₂₀ClNO₄, was synthesized by the reaction of meth­yl 3-(2-chloro­phen­yl)-2-cyano­acrylate and 7-meth­oxy-1,2,3,4-tetra­hydro­naphthalen-2-one in ethanol catalyzed by KF-alumina. X-ray analysis reveals that the pyran ring adopts a half-chair conformation, while the cyclo­hexene ring bonded to the pyran moiety has a skew-boat form.

Ethyl 6-amino-5-cyano-2-methyl-4-phenyl-4H-pyran-3-carboxyl­ate

The title compound, C₁₆H₁₆N₂O₃, was synthesized by the reaction of phenyl­methyl­idene­malono­nitrile and ethyl aceto­acetate in the presence of triethyl­benzyl­ammonium chloride in an aqueous medium. The pyran ring adopts a boat conformation. The phenyl ring and the basal plane of the pyran ring make a dihedral angle of 94.5 (2)°. Intermolecular N—H...O and N—H...N hydrogen bonds link the mol­ecules into ribbons along the a axis.

Dieth­yl 2,8-diamino-4,10-bis­(3-nitro­phenyl)naphtho[1,2-b;6,5-b']dipyran-3,9-dicarboxyl­ate dimethyl­formamide disolvate

The title compound, C₃₄H₂₈N₄O₁₀·2C₃H₇NO, was synthesized by the reaction of eth­yl 2-cyano-3-(3-nitro­phen­yl)-1-acrylate and 1,5-naphthalene­diol in the presence of KF-Al₂O₃ in refluxing ethanol. The structure is centrosymmetric and the fused pyran ring adopts a boat conformation.

3-Amino-1-(2-chloro­phenyl)-9-meth­oxy-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

The title compound, C₂₁H₁₇Cl₁N₂O₂, was synthesized by the reaction of 7-meth­oxy-2-tetra­lone, 2-chloro­benzaldehyde and malononitrile in the presence of triethyl­benzyl­ammonium chloride in an aqueous medium. X-ray analysis reveals that the pyran ring and the fused six-membered ring adopt boat and half-chair conformations, respectively.

2,3a-trans-1,3a-cis-1,2-Bis(4-chloro­phen­yl)-1',2',3'-trihydro-3a-hydr­oxy­benzo[e]bicyclo­[3.3]octane-3-spiro-2'-indene-1'-one acetone solvate

The title compound, C₃₂H₂₄Cl₂O₂·C₃H₆O, was synthesized by the dimerization of 2-(4-chloro­benzal)inden-1-one, induced by a low-valent titanium reagent (TiCl₄/Zn). X-ray analysis reveals that the cyclo­pentane ring spiro-fused to the five-membered ring adopts an envelope conformation, while the other cyclo­pentane ring adopts an envelope conformation.

1,3-trans-1,4-cis-1,2-Bis(2,4-dichloro­phen­yl)-1,2,3,3a,8,8a-hexa­hydro­benzo[e]penta­lene-3-spiro-2'-indan-3a,1'-diol acetone solvate

The title compound, C₃₂H₂₄Cl₄O₂·C₃H₆O, was obtained as a by-product of the reaction of 2-(2',4'-dichloro­benzal)-1-inden-1-one induced by a low-valent titanium reagent (TiCl₄/Zn). Each of the fused cyclo­pentane rings adopts an envelope conformation.

Methyl 2-methyl-5-oxo-4-p-tolyl-1,4,5,6,7,8-hexa­hydro­quinoline-3-carboxylate

The title compound, C₁₉H₂₁NO₃, was synthesized by the reaction of cyclo­hexane-1,3-dione, 4-methyl­benzaldehyde and methyl 3-amino­but-2-enoate in the presence of benzyl­triethyl­ammonium chloride in an aqueous medium. X-ray single-crystal analysis reveals that the heterocyclic ring and the fused six-membered ring adopt boat and envelope conformations, respectively. In the crystal structure, mol­ecules are linked by inter­molecular N—H...O hydrogen bonds.

Ethyl 5-cyano-4-(2,3-dimethoxy­phen­yl)-2-methyl-6-oxopyridine-3-carboxyl­ate

The title compound, C₁₈H₁₈N₂O₅, was synthesized from 2,3-dimethoxy­phenyl­methyl­idenemalononitrile and ethyl aceto­acetate in the presence of triethyl­benzyl­ammonium chloride in an aqueous medium. The pyridone and benzene rings make a dihedral angle of 63.8 (1)°. There are inter­molecular C—H...O and N—H...O hydrogen bonds.

Ethyl 5-amino-1-(4-chloro­phenyl-5,5-dimethyl-2-oxo-1,3,2-dioxaphosphinan-2-yl)-3-(6-chloro-3-pyridylmethyl­amino)-1H-pyrazole-4-carboxyl­ate

In the title compound, C₂₃H₂₆Cl₂N₅O₅P, the P atom adopts a distorted tetra­hedral coordination. The terminal ethyl carboxyl­ate group is almost coplanar with the plane of the pyrazole ring. Intra­molecular N—H...O hydrogen bonds influence the overall conformation of the mol­ecule. C—H...π Inter­actions contribute to the crystal packing.

cis-Ethyl 5-amino-1-[4-(4-chloro­phenyl)-5,5-dimethyl-2-oxo-1,3,2-dioxaphosphinan-1-yl]-3-(6-chloro-3-pyridylmethyl­amino)-1H-pyrazole-4-carboxyl­ate

In the title compound, C₂₃H₂₆Cl₂N₅O₅P, the P atom adopts a distorted tetra­hedral configuration. The carboxyl fragment of the ethyl­carboxyl­ate group is almost coplanar with the pyrazole ring. The dihedral angle between the pyrazole and pyridine rings is 82.7 (1)°. Intra­molecular C—H...O, C—H...N and N—H...O hydrogen bonds contribute strongly to the stability of the mol­ecular configuration. C—H...O inter­molecular hydrogen bonds link inversion-related mol­ecules into a centrosymmetric R₂²(10) dimer. In addition, C—H...π hydrogen bonds are observed in the crystal structure.

trans-4-(4-Chloro­phen­yl)-2-[(2-chloro­phen­yl)(3-pyridylmethyl­amino)meth­yl]-5,5-dimethyl-1,3,2-dioxaphosphinane 2-oxide

In the title compound, C₂₄H₂₅Cl₂N₂O₃P, the P atom adopts a distorted tetra­hedral configuration. Weak inter­molecular N—H...N and C—H...O hydrogen bonds are observed, and C—H...π inter­actions also contribute to the crystal packing.