Carboplatin binding to histidine

S. W. M. Tanley, K. Diederichs, L. M. J. Kroon-Batenburg, C. Levy, A. M. M. Schreurs and J. R. Helliwell

An X-ray crystal structure showing the binding of purely carboplatin to histidine in a model protein has finally been obtained. This required extensive crystallization trials and various novel crystal structure analyses.

Keywords: carboplatin; histidine; avoid partial conversion to cisplatin; NaBr crystallization conditions; non-NaCl crystallization conditions; model protein (hen egg-white lysozyme).

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