crystallization communications
GIM-1 is a member of the class B carbapenemases and has a wide spectrum of activity against carbapenems, penicillins and extended-spectrum cephalosporins, but not aztreonam. In this study, GIM-1 was cloned, overexpressed and crystallized.
crystallization communications
Cystathionine γ-synthase (CGS) catalyzes the γ-replacement reaction of O-succinylhomoserine and L-cysteine to form L-cystathionine and succinate. As an antibacterial drug target, CGS from X. oryzae pv. oryzae (XometB) was cloned, purified and crystallized, and a preliminary X-ray crystallography analysis of the XometB crystal was performed.