Crystallization and preliminary diffraction studies of GIM-1, a class B carbapenem-hydrolyzing β-lactamase

M.-K. Hong, J. H. Lee, D. B. Kwon, J.-K. Kim, T.-H. Tran, D.-D. Nguyen, B. C. Jeong, S. H. Lee and L.-W. Kang

GIM-1 is a member of the class B carbapenemases and has a wide spectrum of activity against carbapenems, penicillins and extended-spectrum cephalosporins, but not aztreonam. In this study, GIM-1 was cloned, overexpressed and crystallized.

Keywords: antibiotic resistance; metallo-β-lactamases; GIM-1; drug targets.

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Crystallization and preliminary diffraction studies of GIM-1, a class B carbapenem-hydrolyzing β-­lactamase

Crystallization and preliminary diffraction studies of GIM-1, a class B carbapenem-hydrolyzing β-lactamase