Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain

J. Granzin, Y. Huang, C. Topbas, W. Huang, Z. Wu, S. Misra, S. L. Hazen, R. E. Blanton, X. Lee and O. H. Weiergräber

The crystal structure of ShSPI, a serpin from the blood fluke S. haematobium, reveals some peculiar features of the helical subdomain which have not been observed previously in the serpin superfamily.

Keywords: serpins; Schistosoma haematobium; protease inhibitors; parasites.

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