Latent and active abPPO4 mushroom tyrosinase cocrystallized with hexatungstotellurate(VI) in a single crystal

Mushroom tyrosinase isoform abPPO4 (Agaricus bisporus polyphenol oxidase 4) was crystallized by means of an Anderson-type polyoxometalate. The enzyme crystallized as a crystallographic heterodimer containing the zymogen (L-TYR; 64 kDa), the 21 kDa smaller activated form (A-TYR) and the polyoxometalate (POM) within one single crystal in a 1:1:1 ratio.