Download citation
Download citation

link to html
Crystal structure analyses of the monooxygenase TetX in complex with tigecycline and minocycline support the observation that all clinically available tetracycline antibiotics can be inactivated by enzymatic hydroxylation. Molecular-dynamics simulations of dioxygen diffusion and experimental xenon-binding sites in TetX are compared with respect to putative dioxygen-binding cavities and dioxygen-diffusion pathways.
Follow Acta Cryst. D
Sign up for e-alerts
Follow Acta Cryst. on Twitter
Follow us on facebook
Sign up for RSS feeds