research papers
The de novo structure of coniferyl alcohol 9-O-methyltransferase and ITC measurements suggest a novel binding mode and reaction mechanism in plant small-molecule O-methyltransferases.
research papers
The simultaneous filling of the ribose-33 and ribose-34 pockets at the active site of Z. mobilis tRNA-guanine transglycosylase was investigated using a series of bifunctionalized lin-benzopurine inhibitors. A strong influence of the crystallization protocol on the solvation pattern and the residual mobility of the bound ligands was observed in the cocrystal structures.