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A 1.4 Å resolution crystal structure of wild-type human cardiac troponin C regulatory domain (cNTnC) in complex with Cd2+ is compared with structures of other EF-hand containing proteins that have been cocrystallized with Cd2+. Structures of cNTnC with disease-related mutations L29Q and NIQD (D2N/V28I/L29Q/G30G) are also determined.
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