research papers
The crystal structure of the C-terminal half of human XPB helicase was determined to 1.8 Å resolution. A disease-causing mutation (XP11BE) at the C-terminus produces a less soluble XPB mutant, significantly reducing the cellular level of the TFIIH complex.
Keywords: DNA repair; transcription; xeroderma pigmentosum; Cockayne syndrome; cancer; premature ageing.