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A small footprint detector has been designed, built and commissioned for X-ray fluorescence applications. It provides an active area of greater than 90% compared with 36% of the conventional design.

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XAFS provides local structure of the metal site at subatomic resolution and is equally applicable to both aqueous and crystalline samples. This review provides some recent case studies to illustrate its synergy with protein X-ray crystallographic determination. This synergy exists not only for the scientific objective of structure-based understanding of proteins' function but extends to the source and general instrument requirements, particularly with MAD.

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