High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase

Lipocalin-type prostaglandin D synthase (L-PGDS) is the first member of the important lipocalin family to be recognized as an enzyme. The X-ray structures of nine crystal forms of one single mutant, three double mutants and a triple mutant of human L-PGDS have been solved.