Crystallographic study of the phosphoethanolamine transferase EptC required for polymyxin resistance and motility in Campylobacter jejuni

The C. jejuni phosphoethanolamine transferase EptC functions in antibacterial resistance, motility and host intestinal colonization. In this study, the three-dimensional structure of the catalytic domain of EptC is reported in a covalent phosphoenzyme-intermediate state. EptC active-site mutant strains of C. jejuni demonstrate the potential for EptC enzyme inhibitors.