L-allo-Threonine aldolase with an H128Y/S292R mutation from Aeromonas jandaei DK-39 reveals the structural basis of changes in substrate stereoselectivity

H.-M. Qin, F. L. Imai, T. Miyakawa, M. Kataoka, N. Kitamura, N. Urano, K. Mori, H. Kawabata, M. Okai, J. Ohtsuka, F. Hou, K. Nagata, S. Shimizu and M. Tanokura

The crystal structures of A. jandaei L-allo-threonine aldolase and a mutant were refined to 2.59 and 2.50 Å resolution, respectively. The structural basis of the substrate specificity and stereoselectivity has been elucidated.

Keywords: L-allo-threonine aldolase; pyridoxal 5′-phosphate; stereoselectivity; α/β domain.

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