Structural insights into the catalytic mechanism of human squalene synthase

The structures of human squalene synthase and its mutants in complex with several substrate analogues and intermediates coordinated with Mg²⁺ or Mn²⁺ stepwise delineate the biosynthetic pathway.

Structural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor binding

A metal-independent glutaminyl cyclase from the black-legged tick I. scapularis is reported. The metal-independent inhibition of glutaminyl cyclases by imidazole-derived inhibitors is described for the first time.