Structural insights into the catalytic mechanism of human squalene synthase

C.-I. Liu, W.-Y. Jeng, W.-J. Chang, M.-F. Shih, T.-P. Ko and A. H.-J. Wang

The structures of human squalene synthase and its mutants in complex with several substrate analogues and intermediates coordinated with Mg²⁺ or Mn²⁺ stepwise delineate the biosynthetic pathway.

Keywords: squalene synthase; cholesterol synthesis; nicotinamide adenine dinucleotide; farnesyl pyrophosphate; terpenoids.

Read article Similar articles

Format		BIBTeX
		EndNote
		RefMan
		Refer
		Medline
		CIF
		SGML
		Text
		Plain Text

Format		BIBTeX
		EndNote
		RefMan
		Refer
		Medline
		CIF
		SGML
		Text
		Plain Text

Search IUCr Journals		doi		Advanced search
Author		volume	page