Acta Crystallographica Section D
Acta Crystallographica
Section D
STRUCTURAL BIOLOGY
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Acta Cryst.
(2013).
D
69
,
2403-2411
https://doi.org/10.1107/S0907444913022269
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Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer
I. Russo Krauss
,
A. Pica
,
A. Merlino
,
L. Mazzarella
and
F. Sica
The structure of the thrombin-HD22-27mer complex, solved at 2.4 Å resolution, reveals an intriguing duplex-quadruplex folding of the aptamer, which extensively interacts with the exosite II of the protein.
Keywords:
thrombin
;
aptamers
;
duplex-quadruplex motifs
.
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