Download citation
Download citation

link to html
The enzymatic and structural characterization of the drug target purine-specific nucleosidase from the pathogen T. brucei provides a rationale for the tight-binding inhibition by iminoribitol-based compounds. The binding of a metalorganic inhibitor to nucleoside hydrolases is reported for the first time, together with the structural basis of metal-mediated noncompetitive inhibition.
Follow Acta Cryst. D
Sign up for e-alerts
Follow Acta Cryst. on Twitter
Follow us on facebook
Sign up for RSS feeds