The structure of the deacetylase domain of Escherichia coli PgaB, an enzyme required for biofilm formation: a circularly permuted member of the carbohydrate esterase 4 family

Biofilm is an extracellular matrix created by many microorganisms, and a major problem in clinical and technical settings. The crystal structure reported here helps elucidate the synthesis of the major component of biofilm produced by Y. pestis and E. coli, and may assist in the development of agents to block it.