Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors

Crystal structures of peptide deformylase from S. aureus in complex with novel inhibitors are presented together with their functional analysis. A detailed comparative analysis of these structures as well as the activities of the inhibitors allowed the elucidation of distinctive structural changes which depend upon the class of inhibitor.

Structures of the ribosome-inactivating protein from barley seeds reveal a unique activation mechanism

Crystal structures of ribosome-inactivating protein (RIP) from barley seeds have been determined in free, AMP-bound and adenine-bound states. These data revealed a unique activation mechanism for a type I RIP from a monocotyledonous crop.