Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors

Crystal structures of peptide deformylase from S. aureus in complex with novel inhibitors are presented together with their functional analysis. A detailed comparative analysis of these structures as well as the activities of the inhibitors allowed the elucidation of distinctive structural changes which depend upon the class of inhibitor.

Induced-fit motion of a lid loop involved in catalysis in alginate lyase A1-III

The structures of apo and holo mutants of alginate lyase A1-III revealed a large open/closed conformational change of lid loop. The closed lid loop is involved both in the binding of substrate and catalysis of the enzyme.