Structure of the DNA (6-4) photoproduct dTT(6-4)TT in complex with the 64M-2 antibody Fab fragment implies increased antibody-binding affinity by the flanking nucleotides

The crystal structure of the DNA photoproduct dTT(6-4)TT in complex with an antibody Fab indicates that the central dT(6-4)T segment is fully accommodated in the concave pocket and its flanking 5'-side thymidylate and 3'-side phosphate groups are responsible for the increased antibody-binding affinity of longer photoproducts.