rac-Methyl (1R,3′S)-1′,1′′-dimethyl-2,2′′-dioxo-2H-dispiro­[acenaphthyl­ene-1,2′-pyrrolidine-3′,3′′-indoline]-4′-carboxyl­ate

In the title compound, C₂₆H₂₂N₂O₄, the pyrrolidine ring adopts a twisted conformation and the other five-membered rings adopt envelope conformations with the spiro C atoms as the flap atoms. The naphthalene ring system of the dihydro­acenaphthyl­ene group forms dihedral angles of 89.2 (9) and 75.5 (6)° with the pyrrolidine and indole rings, respectively. The pyrrolidine ring makes a dihedral angle of 80.1 (9)° with the indole ring. In the crystal, mol­ecules are linked by weak C—H...O hydrogen bonds, forming chains along the b-axis direction.

cis-Bromido(methyl­amine)­bis­(propane-1,3-di­amine)­cobalt(III) dibromide

In the title compound, [CoBr(CH₅N)(C₃H₁₀N₂)₂]Br₂, the cobalt^III ion has a distorted octa­hedral coordination environment and is surrounded by four N atoms in the equatorial plane, with an additional N atom and the Br atom occupying the axial positions. In the crystal, the complex cation and the two counter anions are linked via N—H...Br and C—H...Br hydrogen bonds, forming a three-dimensional network.

trans-Diamminedichloridobis(1H-imidazole-κN³)nickel(II)

The whole mol­ecule of the title compound, [NiCl₂(C₃H₄N₂)₂(NH₃)₂], is generated by inversion symmetry. The Ni^II ion, which is located on an inversion center, has a distorted octa­hedral coordination environment and is surrounded by two ammine N atoms and two Cl atoms in the equatorial plane, with two N atoms of two imidazole groups occupying the axial positions. The imidazole ring makes a dihedral angle of 81.78 (18)° with the Ni/N/Cl equatorial plane. In the crystal, mol­ecules are linked via N—H...Cl hydrogen bonds and C—H...π inter­actions, forming a three-dimensional network.

A diastereomer of methyl (1R,3′S)-1′,1′′-dimethyl-2,2′′-dioxo-2H-dispiro­[ace­naphthyl­ene-1,2′-pyrrolidine-3′,3′′-indoline]-4′-carboxyl­ate

In the title compound, C₂₆H₂₂N₂O₄, the central pyrrolidine ring adopts a twist conformation and the cyclo­pentane ring of the dihydro­acenapthylene group adopts an envelope conformation with the spiro C atom as the flap. The naphthalene ring system of the dihydro­acenaphthyl­ene group forms dihedral angles of 83.4 (9) and 61.3 (7)°, respectively, with the mean planes of the pyrrolidine and indole rings. The crystal packing is stabilized by inter­molecular C—H...O hydrogen bonds. The title compound is a diastereomer of a previously reported structure.

(3E)-11,16-Dioxatricyclo­[15.4.0.0^5,10]henicosa-1(21),3,5,7,9,17,19-heptaen-2-one

The title compound, C₁₉H₁₈O₃, crystallizes with three mol­ecules (A, B and C) in the asymmetric unit. The carbonyl O atom shows positional disorder over two sites in mol­ecules A and B; the site-occupancy ratios are 0.76 (3):0.24 (3) and 0.86 (3):0.14 (3), respectively. The ethyl­ene fragments in each mol­ecule have an E conformation, while the C—O—C—C torsion angles indicate near planarity. The dihedral angles formed by the aromatic rings are 20.0 (1), 23.7 (1) and 16.1 (1)° for mol­ecules A, B and C, respectively. Intra­molecular C—H...O hydrogen bonds occur in each mol­ecule.

N-[(1E)-5-(3-Chloro­phen­yl)-3-methyl­cyclo­hex-2-en-1-yl­idene]hydroxyl­amine

The whole of the title mol­ecule, C₁₃H₁₄ClNO, is disordered over two sets of sites with a refined occupancy ratio of 0.560 (6):0.440 (6). The oxime group having a C=N double bond adopts an E conformation. The dihedral angles between the rings (all atoms) are 89.5 (5) (major componenent) and 88.0 (6)° (minor component).

cis-Di­aqua­tetra­kis­(1-butyl-1H-imidazole-κN³)nickel(II) dichloride

In the title compound, [Ni(C₇H₁₂N₂)₄(H₂O)₂]Cl₂, the nickel(II) ion has a distorted octa­hedral coordination environment. It is surrounded by three N atoms and one O atom occupying the equatorial plane, and one N and one O atom in the axial positions. The imidazole ring systems are inclined to one another with dihedral angles varying between 38.3 (4) and 74.1 (4)°. In the crystal, mol­ecules are linked via O—H...Cl hydrogen bonds involving one Cl⁻ anion and the water mol­ecule in the equatorial plane, forming an inversion dimer-like arrangement. The water mol­ecule in the axial position is hydrogen-bonded to both Cl⁻ anions. There are also a number of C—H...Cl hydrogen bonds present, forming a three-dimensional structure. All four alkyl chains are disordered over two positions with refined occupancy ratios of 0.395 (15):0.605 (15), 0.658 (14):0.342 (14), 0.332 (11):0.668 (11) and 0.622 (12):0.378 (12).

Di­aqua­dichlorido­bis­(pyridine-κN)cobalt(II)

The title mol­ecule, [CoCl₂(C₅H₅N)₂(H₂O)₂], has -1 symmetry with the Co^II ion situated on an inversion centre. The cation has a distorted octa­hedral coordination environment and is surrounded by two N and two Cl atoms in the equatorial plane, while the coordinating water O atoms occupy the axial positions. The crystal exhibits nonmerohedral twinning with two domain states, the volume fractions of which were refined to 0.883 (2) and 0.117 (3). The crystal packing is stabilized by O—H...Cl hydrogen-bond inter­actions, forming two-dimensional networks lying parallel to (001). The crystal packing also features π–π inter­actions between the pyridine rings, with centroid–centroid separations of 3.493 (3) and 3.545 (3) Å.

Ethyl 1′′-benzyl-1′-methyl-2′′-oxodi­spiro­[indeno­[1,2-b]quinoxaline-11,3′-pyrrolidine-2′,3′′-indoline]-4′-carboxyl­ate

In the title compound, C₃₆H₃₀N₄O₃, the quinoxaline–indene system is roughly planar, with a maximum deviation from the mean plane of 0.218 Å for the C atom shared with the central pyrrolidine ring. This latter ring forms dihedral angles of 84.54 (7) and 83.91 (8)° with the quinoxaline–indene system and the indole ring, respectively. The central pyrrolidine ring has an envelope conformation with the N atom as the flap, while the pyrrolidine and five-membered rings of the indole group adopt twisted conformation and envelope (with the C atom bearing the quinoxaline–indene system as the flap) conformations, respectively. In the crystal, mol­ecules are linked via weak C—H...N hydrogen bonds, forming a chain running along [100].

Methyl (3S,10b'S)-5-chloro-9′-fluoro-1-methyl-2-oxo-5′-phenyl-10b'H-spiro­[indoline-3,1′-pyrazolo­[3,2-a]iso­quinoline]-2′-carboxyl­ate

In the title compound, C₂₇H₁₉ClFN₃O₃, the pyrazole ring has a twist conformation and the six-membered ring to which it is fused has a screw-boat conformation. The mean plane of the pyrazole ring is inclined to the 2-methyl­indoline ring by 85.03 (9) and by 28.17 (8)° to the mean plane of the iso­quinoline ring system. In the crystal, mol­ecules are linked by pairs of C—H...F hydrogen bonds, forming inversion dimers. These dimers are linked via C—H...O hydrogen bonds, forming a two-dimensional network lying parallel to (10-1).

Methyl 5′′-chloro-1′,1′′-dimethyl-2,2′′-dioxodi­spiro­[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carboxyl­ate

In the title compound, C₂₂H₂₀ClN₃O₄, the central pyrrolidine ring adopts an envelope conformation on the N atom. The indolinone systems are individually roughly planar, with maximum deviations from their mean planes of 0.130 Å for the spiro C atom of the indolinone unit and 0.172 Å for the carbonyl C atom of the 5-chloro-1-methyl­indolinone unit. They make dihedral angles of 77.7 (8) and 86.1 (8)° with the mean plane through the central pyrrolidine ring. In the crystal, mol­ecules are linked by N—H...O hydrogen bonds supported by C—H...O contacts into chains along the ab diagonal. The structure also features C—H...O hydrogen bonds, forming R₂²(8) and R₂²(16) rings and generating a three-dimensional array.

Ethyl 1′′-benzyl-2′′-oxo-2′,3′,5′,6′,7′,7a'-hexa­hydro-1′H-di­spiro­[indeno­[1,2-b]quinoxaline-11,2′-pyrrolizine-3′,3′′-indoline]-1′-carboxyl­ate monohydrate

In the title compound, C₃₈H₃₂N₄O₃·H₂O, the quinoxaline–indene and pyrrolizine systems are essentially planar, with maximum deviations from their mean planes of 0.162 and 0.563 Å, respectively. The pyrrolizine ring forms dihedral angles of 88.53 (5) and 89.95 (8)° with the quinoxaline–indene system and the indoline ring, respectively. The central pyrrolidine ring has an envelope conformation with the C atom bearing the quinoxaline-indene system as the flap. The pyrrolidine ring of the indole system adopts an envelope conformation with the C atom bonded to the pyrrolizine ring N atom as the flap. The five-membered ring attached to the central pyrolidine ring adopts a twisted conformation. In the crystal, O—H...N and O—H...O hydrogen bonds between water mol­ecules and pyrrolizine N and carbonyl O atoms together with C—H...O inter­actions result in chains along [100].

Methyl 2-(5-chloro-1-methyl-2-oxo-2,3-di­hydro-1H-indol-3-ylidene)acetate

The title compound, C₁₂H₁₀ClNO₃, the indoline ring system is essentially planar, with a maximum deviation of 0.009 Å for the N atom. The indoline ring and acetate group are essentially coplanar, with a maximum deviation of 0.086 Å for the O atom. The mean plane through the methoxy­carbonyl­methyl group forms a dihedral angle of 3.68 (5)° with the plane of the indoline ring system. The mol­ecular structure is stabilized by an intra­molecular C—H...O hydrogen-bond inter­action. In the crystal, π–π stacking inter­actions [centroid–centroid distance = 3.7677 (8) Å] occur between benzene rings, forming a chain running along the c-axis direction.

6′-(1,3-Diphenyl-1H-pyrazol-4-yl)-7′-(1H-indol-3-ylcarbon­yl)-2-oxo-1-(prop-2-en-1-yl)-5′,6′,7′,7a'-tetra­hydro-1′H-spiro­[indoline-3,5′-pyrrolo­[1,2-c][1,3]thia­zole]-7′-carbo­nitrile

In the title compound, C₄₁H₃₂N₆O₂S, the pyrrolo­thia­zole ring system is folded about the bridging N—C bond. The thia­zolidine and pyrrolidine rings adopt envelope (with the fused C atom as the flap) and twisted conformations, respectively. The two phenyl rings attached to the pyrazole ring are twisted from the plane of the latter by 6.8 (1) and 52.8 (1)°. The allyl group is disordered over two conformations in a 0.805 (6):0.195 (6) ratio. In the crystal, pairs of N—H...O hydrogen bonds link the mol­ecules into centrosymmetric dimers.

Ethyl 8′′-chloro-1′-methyl-2,12′′-dioxo-12′′H-di­spiro­[indoline-3,2′-pyrrolidine- 3′,6′′-indolo[2,1-b]quinazoline]-4′-carboxyl­ate

In the title compound, C₂₉H₂₃ClN₄O₄, the quinazoline-indole system and the indolin-2-one system are each essentially planar, with maximum deviations from their mean planes of 0.150 (2) and 0.072 (2) Å, respectively. The central pyrrolidine ring adopts a twisted conformation on the C—C bond involving the spiro C atoms. Its mean plane forms dihedral angles of 83.37 (9) and 86.56 (8)°, respectively, with the indole rings of the indolin-2-one and quinazoline-indole systems. In the crystal, mol­ecules are linked via pairs of N—H...O hydrogen bonds, forming inversion dimers. The dimers are linked via C—H...O hydrogen bonds, forming chains propagating along [001].