Structure of the N-terminal domain of human thioredoxin-interacting protein

The crystal structure of the N-terminal domain of human thioredoxin-interacting protein (TXNIP), which belongs to a recently classified α-arrestin protein family, has been determined. This study provides the first structural information on any of the α-arrestins. Although TXNIP adopts a β-arrestin fold as predicted, it is structurally more similar to Vps26 proteins than to β-arrestins, while sharing below 15% pairwise sequence identity with either.