X-ray study of the conformational changes in the molecule of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis during the catalyzed reaction

Based on the X-ray structures of apo PPATMt and its complexes with functionally important ligands (ATP and dPCoA) determined in the current work and in previous work, the conformational changes which accompany the reaction catalyzed by the enzyme have been studied.