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organic compounds
In the title compound, 2C14H19N4O3+·C7H3NO42−·5H2O, the asymmetric unit contains two trimethoprim cations (A and B), a dipicolinate anion and five water molecules. One of the picolinate carboxylate groups interacts with cation A via a pair of N—H
O hydrogen bonds, forming a ring motif 
(8). A loop of O—HO hydrogen bonds is formed between four water molecules and the two carboxylate groups to form a supramolecular chain along the a axis. Molecules A and B constitute a base pair via N—HN hydrogen bonds, and these base pairs are cross-linked by N—HO and C—HO hydrogen bonds.
O hydrogen bonds, forming a ring motif 
(8). A loop of O—HO hydrogen bonds is formed between four water molecules and the two carboxylate groups to form a supramolecular chain along the a axis. Molecules A and B constitute a base pair via N—HN hydrogen bonds, and these base pairs are cross-linked by N—HO and C—HO hydrogen bonds.organic compounds
The title compound [systematic name: ent-3β-hydroxy-8(17),13(14)-labdadiene-16,15-olide], C20H30O4, contains two trans fused six-membered rings, with a lactone ring at the end of an equatorial side chain. The six-membered rings are in chair conformations and the lactone ring is planar. There is an infinite chain of both inter- and intramolecular O—HO hydrogen bonds along the b axis. The present study is a confirmation of the results of previous structure determinations of 14-deoxyandrographolide by Medforth, Chang, Chen, Olmstead & Smith [J. Chem. Soc. Perkin Trans. 2 (1990), pp. 1011--1016] and Rajnikant, Gupta, Singh, Lal, Gupta & Varghese [Mol. Cryst. Liq. Cryst. Sect. C (1996), 6, 227–233].
O hydrogen bonds along the b axis. The present study is a confirmation of the results of previous structure determinations of 14-deoxyandrographolide by Medforth, Chang, Chen, Olmstead & Smith [J. Chem. Soc. Perkin Trans. 2 (1990), pp. 1011--1016] and Rajnikant, Gupta, Singh, Lal, Gupta & Varghese [Mol. Cryst. Liq. Cryst. Sect. C (1996), 6, 227–233].
