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The structure of the title compound, 2-methyl-1-(1,2,3,9-tetra­hydro-9-methyl-4-oxo-4H-carbazol-3-yl­methyl)-1H-imid­azol-3-ium chloride dihydrate, C18H24N3+·Cl-·2H2O, has been reported previously by Collin, Moureau, Quintero, Vercauteren, Evrard & Durant [(1995). J. Chem. Soc. Perkin Trans. 2, pp. 77-84] and Chandra Mohan & Ravikumar, [(1995), Acta Cryst. C51, 2627-2629]. In both determinations, all atoms were refined as clearly ordered. In contrast to this, we present here a redetermination of this structure from new intensity data where two atoms of the cyclo­hexenone ring are disordered over two sites. Apart from this disorder, our results agree with the already published data.

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The title compound [systematic name: (\pm)-5-({4-[2-(5-ethyl-2-pyridinio)­ethoxy]­phenyl}methyl)­thia­zolidine-2,4-dione chlor­ide], C19H21N2O3S+·Cl, is an oral antidiabetic agent. In the crystal structure, the mol­ecules are linked by N—H...Cl hydrogen bonds into chains.

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Valdecoxib, C16H14N2O3S, is a non-steroidal anti-inflammatory drug containing a planar isoxazole heterocycle which is substituted at the C atoms with two aromatic rings and a methyl group. In addition to one mol­ecule of valdecoxib, there is half a mol­ecule of ethyl methyl ketone in the asymmetric unit of the title compound [systematic name: 4-(5-methyl-3-phenyl­isoxazol-4-yl)­benzene­sulfon­amide ethyl methyl ketone hemisolvate], viz. C16H14N2O3S·0.5C4H8O. The crystal packing is stabilized by N—H...O hydrogen bonds. Apart from the orientation of the sulfon­amide group, the conformation of the title compound agrees well with that of the recently published orthorhombic polymorph which does not contain any solvent.

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The title compound, C8H5BrO2, serves as a starting material for the synthesis of citalopram. It crystallizes with two almost identical mol­ecules in the asymmetric unit.

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Supramolecular assembly of the title compound, C12H14ClFN2O, is primarily governed by N—H+...Cl and C—H...O interactions, and a putative C—H...F interaction. The piperidine ring assumes a chair conformation, with the substituted benzisoxazole ring in an equatorial position.

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Sildenafil citrate is well known as Viagra for the treatment of erectile dysfuncion. In the title compound (systematic name: 1-{[3-(6,7-Di­hydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo­[4,3-d]­pyrimidin-5-yl)-4-ethoxy­phenyl]­sulfonyl}-4-methyl­piper­az­in­ium citrate monohydrate), C22H31N6O4S+·C6H7O7-·H2O, the pyrazolopyrimidone ring system and the benzene ring are almost coplanar, enabling an intramolecular hydrogen bond between the pyrazolopyrimidone NH group and the O atom of the ethoxy group. One of the N atoms of the piperazine ring is protonated and the citrate mol­ecule exists as an anion. The crystal packing is stabilized by several hydrogen bonds.

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The structure of the title compound, C6H13ClNO+·Cl-, comprises a cation with the morpholine ring in the chair conformation, and a single hydrogen-bonding association between the morpholinium NH group and the Cl- anion.

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Molecules of the title compound, C9H15NO3, form a two-dimensional hydrogen-bonded network, via O—H...O and N—H...O interactions, which runs parallel to the bc plane. In this structure, neither the carboxyl­ic acid groups nor the carbamoyl groups are involved in dimer formations.

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The structure of the title compound, C13H16O4, comprises a non-planar chiral mol­ecule where the cyclo­hexene double bond is distinctly shorter [1.335 (2) Å] than the neighbouring C-C single bonds (>1.4 Å).

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The title compound, C22H20ClN3O, (I), is used as an inter­mediate for the synthesis of the antihypertensive drug losartan. Bond lengths and angles are unexceptional. The crystal packing is stabilized by one C—H...O and one C—H...N contact. It is noteworthy that (I) is isomorphous with a closely related compound which differs in having a but-2-en­yl chain instead of a but­yl chain on the imidazole ring.

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The structure of the title compound, C16H14N2O2, contains a seven-membered ring that adopts a boat conformation, and the overall molecular shape is that of a butterfly. In the packing, the mol­ecules form a convoluted hydrogen-bonded polymer via a typical R22(8) graph-set dimer, between carbox­amide groups, and an R22(16) graph-set dimer formed through an interaction between the second carbox­amide NH group and an adjacent methoxy O atom (in each mol­ecule). The dihedral angle between the benzene rings is 56.09 (5)°.

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The title compound, C14H12ClNO, is used in perfumery, as a catalyst for the polymerization of olefins, and in organic synthesis, especially as a photosensitizer and in the manufacture of dyes. The mol­ecule is essentially planar and has a trans configuration. In this configuration, the Cl and O atoms shield the amino H atom, preventing the formation of an inter­molecular hydrogen bond.

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In the title compound, 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione, C15H11ClN2S, the central seven-membered diazepinethione ring adopts a boat conformation. The dihedral angle between the planes of the aromatic rings is 63.7 (1)°. The crystal packing is determined by strong N—H...N hydrogen bonds, generating a one-dimensional chain along [001].
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