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In the title mol­ecule, C20H22N2O4S, the pyrimidine ring is in a flattened half-chair conformation and the 3-meth­oxyphenyl substituent is in an axial arrangement. The thia­zole ring forms a dihedral angle of 81.3 (1)° with the benzene ring. In the crystal, weak C—H...S inter­actions link mol­ecules into chains along [001]. In addition, there are π–π inter­actions between inversion-related thia­zole rings with a centroid–centroid distance of 3.529 (2) Å. The ethyl group was refined as disordered over two sets of sites with an occupancy ratio of 0.52 (3):0.48 (2).
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