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The tricyclic aromatic ring system of the title compound, C15H9Cl2N, is essentially planar (r.m.s. deviation = 0.002 Å). The two Cl atoms lie slightly out of the plane of the carbazole ring system, with the C—Cl bonds forming angles of 1.23 (8) and 1.14 (8)° with the plane. The acetylene group has a syn orientation with respect to the ring system. In the crystal, no weak hydrogen bonds nor any π–π stacking inter­actions are observed.

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The structure of a hydroacridine with significant pharmaceutical potential is reported. The acridinone ring system is in the shape of a shallow V with the majority of the ring system substituents on its convex surface; a plethora of classical and non-classical hydrogen bonds stack the molecules into interconnected columns.

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In the title compound, C15H10ClN3O2, the benzene ring is slightly twisted out of the plane of the 2,3-di­hydro-1H-indole ring system (r.m.s. deviation = 0.007 Å), forming a dihedral angle of 7.4 (3)°. An intra­molecular N—H...O hydrogen bond forms a six-membered ring. In the crystal, mol­ecules are linked via N—H...O and C—H...O hydrogen bonds, forming layers alternately perpendicular to [011] and [0-11].

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The mol­ecular conformation of title compound, C12H11N3S, is almost planar [maximum deviation = 0.063 (2) Å]; an intra­molecular C—H...N hydrogen bond is noted. In the crystal, mol­ecules inter­act with each other via π–π stacking inter­actions between thia­zole rings [centroid–centroid distance = 3.7475 (9) Å] and methyl-H...π(C6) inter­actions, forming columns along the a axis.

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In the title compound, C13H13NO3S, the dihedral angle between the benzene rings is 64.15 (7)° and the C—S—N—C torsion angle is −57.18 (12)°. An intra­molecular N—H...O hydrogen bond closes an S(5) ring. In the crystal, O—H...O hydrogen bonds link the mol­ecules into C(8) chains propagating in [100]. Weak C—H...π inter­actions are also observed.

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In the title hydrated molecular salt, C22H18BrN4S+·Br·H2O, the aromatic rings make dihedral angles of 14.20 (12), 34.29 (10) and 68.75 (11)° with the thia­zole ring. In the crystal, mol­ecules are linked into chains running parallel to the a axis by association of the bromide ions and the water mol­ecules of crystallization with the cations via N—H...O, O—H...Br, C—H...N and C—H...Br hydrogen-bonding inter­actions. C—H...π and C—Br...π [3.7426 (11) Å, 161.73 (7)°] inter­actions are also observed, forming infinite chains extending along the b-axis direction.

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The asymmetric unit of the title salt, 2C17H21N2O2S+·C14H14O7P22−, contains half of a centrosymmetric bis­(4-meth­oxy­phen­yl)di­phospho­nate anion and one 2-amino-5-benzyl-3-eth­oxy­carbonyl-4,5,6,7-tetra­hydro­thieno[3,2-c]pyri­din-5-ium cation. In the anion, the O atoms of the di­phospho­nate group are disordered over two positions with equal occupancies. In the cation, the ethyl group is disordered over two orientations with a refined occupancy ratio of 0.753 (5):0.247 (5), and the tetra­hydro­pyridinium ring adopts a distorted half-chair conformation. In the crystal, the ions are linked by C—H...O, N—H...O and C—H...S hydrogen bonds into a three-dimensional network.

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In the title mol­ecule, C18H22N2O2, the furan and benzene rings form a dihedral angle of 70.17 (14)°. In the crystal, strong N—H...O and weak C—H...O hydrogen bonds link the mol­ecules into chains running parallel to [010].

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In the title compound, C14H19N3S, the seven-membered cyclo­heptane ring adopts a chair conformation. An intra­molecular N—H...N hydrogen bond [graph-set motif S(5)] is present in the N—N—C—N chain between the ring systems. An intra­molecular C—H...S contact also occurs. In the crystal, pairs of mol­ecules form centrosymmetric dimers through N—H...S hydrogen bonds [graph-set R22(8)]. These dimers are connected by C—H...S inter­actions with an R22(14) motif.

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In the title compound, C17H17N3O3S, the thia­zole ring is nearly planar [maximum deviation = 0.015 (1) Å for the ring N atom] and the cyclo­pentane ring has a twist conformation. The mol­ecular conformation is stabilized by a hypervalent inter­action between the S atom and the ester group carbonyl O atom, with an S...O distance of 2.7931 (10) Å. In the crystal, C—H...O inter­actions generate chains of mol­ecules propagating along [110] and π–π stacking inter­actions [centroid–centroid distance = 3.4677 (7) Å] between the thia­zole rings organize these chains into (001) layers.

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In the title compound, C12H13N3S, the 4,5-di­hydro-3H-1,2,4-triazole system is nearly planar [maximum deviation = 0.014 (2) Å], while the cyclo­pentane ring adopts a half-chair conformation. The dihedral angle between the mean plane of the 4,5-di­hydro-3H-1,2,4-triazole-3-thione ring and the phenyl ring is 85.49 (14)°, with the S atom 0.046 (1) Å out of the former plane. The crystal structure is stabilized only by van der Waals inter­actions. The investigated crystal was found to be a non-merohedral two-component twin by a 180° rotation about c*, with a refined value of the minor twin fraction of 0.12203 (18).

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In the title compound, C22H19N3O3S, the six-membered ring of the 1,2,3,4-tetra­hydro­naphthalene ring system adopts an envelope conformation with the central CH2 C atom as the flap. The mol­ecular conformation is stabilized by an S...O contact, forming a pseudo-five-membered ring. In the crystal, mol­ecules are linked via C—H...O hydrogen bonds into chains propagating along [102].

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In the title compound, C22H19N4S+·Br·H2O, the dihedral angles between the phenyl groups and the mean plane of the thia­zolyl­idene ring are 34.69 (13) and 64.27 (13)°, respectively, while that between the thia­zolyl­idene and pyridinium rings is 14.73 (13)°. In the crystal, zigzag chains of alternating bromide ions and water mol­ecules associate through O—H...Br inter­actions run in channels approximately parallel to the b axis. These chains help form parallel chains of cations through N—H...O, C—H...N and C—H...Br hydrogen bonds.

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The sample of the title compound, C12H15N3S, chosen for study consisted of triclinic crystals twinned by a 180° rotation about the a axis. The five-membered ring adopts a twisted conformation. The dihedral angle between the phenyl ring and the mean plane of the thio­urea unit is 78.22 (8)°. In the crystal, molecules are linked via pairs of N—H...S hydrogen bonds forming inversion dimers.

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The title compound, C14H10Cl2N2O·H2O, has a nearly planar extended conformation [C—N—N—C = −173.66 (15)°]. The dihedral angle between the aromatic rings is 4.6 (2)°. The water mol­ecules alternate with benzohydrazide mol­ecules in chains formed by O—H...O hydrogen bonds which run parallel to the a axis. These chains are linked to neighboring chains through N—H...O and C—H...O inter­actions, forming a layer parallel to (001).

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In the title compound, C21H19ClN2O2, the benzene ring and the naphthalene ring system are oriented at a dihedral angle of 65.24 (10)°. In the crystal, N—H...O, C—H...N and C—H...O hydrogen bonds link the mol­ecules, forming chains along the b-axis direction. Further C—H...O hydrogen bonds link the chains, forming corrugated sheets lying parallel to (10-1).

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In the title compound, C14H17N3S, the plane of the phenyl ring makes a dihedral angle of 74.90 (4)° with that of the tri­aza­thione ring (r.m.s. deviation = 0.001 Å), while the seven-membered ring adopts a twist-chair conformation. No specific intermolecular interactions are discerned in the crystal packing.

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The title compound, C21H17N3O3, is a new polymorph of an already published structure [Shashidhar et al. (2006). Acta Cryst. E62, o4473–o4475]. The previously reported structure crystallizes in the monoclinic space group C2/c, whereas the structure reported here is in the tetra­gonal space group I41/a. The bond lengths and angles are similar in both structures. The mol­ecule adopts an extended conformation via intra­molecular N—H...O and O—H...N hydrogen bonds; the terminal phenyl ring and the hy­droxy­lphenyl ring are twisted with respect to the central benzene ring by 44.43 (7) and 21.99 (8)°, respectively. In the crystal, mol­ecules are linked by N—H...O hydrogen bonds, weak C—H...O hydrogen bonds and weak C—H...π inter­actions into a three-dimensional supra­molecular network.

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In the title compound, C23H20N3OS+·Br, the di­hydro­thia­zole ring (r.m.s. deviation = 0.015 Å) is twisted with respect to each of the C- and N-bound phenyl rings and the hy­droxy­benzene ring, making dihedral angles of 76.0 (2), 71.2 (2) and 9.8 (2)°, respectively. In the crystal, inversion-related mol­ecules are linked by association of the bromide ions with the cations via N—H...Br and O—H...Br hydrogen-bonding inter­actions. These mol­ecules run in channels parallel to the a axis through face-to-face π–π stacking inter­actions between the hy­droxy­benzene rings [centroid–centroid distances = 3.785 (3) Å] which, in turn, are connected into layers parallel to (110) by weak C—H...π inter­actions. A small region of electron density well removed from the main mol­ecule and appearing disordered over a center of symmetry was removed with PLATON SQUEEZE [Spek (2009). Acta Cryst. D65, 148–15] following unsuccessful attempts to model it as plausible solvent molecule. The nature of the solvent was not known and hence, this is not taken into account when calculating Mr and related data.

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In the title compound, C33H27BrClNO4, the di­hydro­pyridine ring adopts a flattened boat conformation. The mol­ecular conformation is stabilized by an intra­molecular O—H...O hydrogen bond, with an S(8) ring motif. In the crystal, O—H...O, C—H...O and C—H...Cl hydrogen bonds, and C—H...π inter­actions link the mol­ecules, forming a three-dimensional network. In the acridinedione ring system, the two ring C atoms at the 2- and 3-positions, and the C atom at the 6-position and the atoms of the phenyl ring attached to the C atom at the 6-position are disordered over two sets of sites with occupancy ratios of 0.783 (5):0.217 (5) and 0.526 (18):0.474 (18), respectively.

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In the title compound, C20H18BrN3S, the cyclo­pentane ring adopts a half-chair conformation. The 4-bromo­phenyl and phenyl rings make dihedral angles of 34.6 (1) and 68.52 (6)°, respectively, with the di­hydro­thia­zole ring. In the crystal, the mol­ecules pack in sheets approximately parallel to (101) which are formed by weak C—H...Br inter­actions

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In the title mol­ecule, C17H15N3S, the phenyl group makes a dihedral angle of 57.29 (11)° with the mean plane of the triazole ring, which in turn makes an angle of 86.83 (12)° with the plane of the aromatic portion of the tetra­hydro­naphthalene moiety. In the crystal, mol­ecules are linked by weak C—H...S hydrogen bonds into supra­molecular chains propagating along the a-axis direction. Weak C—H...π inter­actions are also observed.

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The title compound, C13H16N4O3S2·H2O, crystallizes in a `folded' conformation with the ester group lying over the carbamoyl moiety, with one solvent water mol­ecule. The mol­ecular conformation is stabilized by an intra­molecular C—H...O hydrogen bond, and an N—H...O hydrogen-bonding inter­action involving the lattice water mol­ecule. The packing involves N—H...N, N—H...O, O—H...N and O—H...O hydrogen bonds and consists of tilted layers running approximately parallel to the c axis, with the ester groups on the outer sides of the layers and with channels running parallel to (101).

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In the title compound, C14H13N5OS, the dihedral angle between the fused ring system (r.m.s. deviation = 0.028 Å) and the phenyl ring is 48.24 (4)°. The mol­ecule features both an intra­molecular N—H...O and an N—H...N hydrogen bond. In the crystal, mol­ecules are linked by N—H...O and N—H...N hydrogen bonds, generating a three-dimensional network. A weak N—H...π inter­action is also observed.

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In the title compound, C16H14N4O2, the pyrazole ring makes a dihedral angle of 10.49 (8)° with its N-bound phenyl group, while it is nearly perpendicular to the other phenyl ring [dihedral angle = 88.47 (5)°]. The mol­ecular conformation is stabilized by intra­molecular C—H...O and N—H...O hydrogen bonds. In the crystal, the packing involves sheets of mol­ecules parallel to (100) linked by N—H...O hydrogen bonds. A C—H...O interaction is also observed.

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The asymmetric unit of the title compound, C10H17N3S, consists of three symmetry-independent mol­ecules with distinctly different conformations, as indicated for example by the C—N—C—C torsion angles of −155.9 (3), 89.9 (3) and 81.1 (4)° along the bond between thio­urea and allyl units. In the crystal, mol­ecules are connected via N—H...N and N—H...S hydrogen bonds into chains extending along [110] that are further associated through C—H...N inter­actions into layers parallel to (001). The allyl group in one of the independent mol­ecules is disordered over two sets of sites with an occupancy ratio of 0.853 (6):0.147 (6).

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The asymmetric unit of the title compound, C16H12ClN3S, contains two independent mol­ecules whose conformations differ primarily in the orientations of the phenyl and chloro­benzene rings with respect to the thia­zole ring. In the first mol­ecule, the dihedral angles are 3.0 (1) and 9.2 (1)°, respectively, for the phenyl ring and the chloro­benzene ring, while in the second mol­ecule, the corresponding angles are 18.6 (1) and 23.4 (1)°. In the crystal, the two independent mol­ecules are associated via complementary N—H...N hydrogen bonds into a dimer. These dimers are associated through weak C—H...Cl and C—H...S inter­actions into supra­molecular chains propagating along the a-axis direction.

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The title compound, C14H15N3O4, is nearly planar, the dihedral angle between the planes of the phenyl and pyrazolidine rings being 1.13 (7) Å, and that between the plane of the pyrazolidine ring and the mean plane of the side chain [C—N—C–C(=O)—O; r.m.s. deviation = 0.024 Å] being 2.52 (7)°. This is due in large part to the presence of the intra­molecular N—H...O and C—H...O hydrogen bonds. In the crystal, pairwise N—H...O hydrogen bonds form inversion dimers, which are further associated into layers, lying very close to plane (-120), via pairwise C—H...O hydrogen bonds. The layers are then weakly connected through C—H...O hydrogen bonds, forming a three-dimensional structure.

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The title salt, C3H5N2+·C10H6NO4, was obtained during a study of the co-crystallization of N′-[bis­(1H-imidazol-1-yl)methyl­ene]isonicotinohydrazide with (1,3-dioxoisoindolin-2-yl)acetic acid under aqueous conditions. The 1,3-dioxoisoindolinyl ring system of the anion is essentially planar [maximum deviation = 0.023 (2) Å]. In the crystal, cations and anions are linked via classical N—H...O hydrogen bonds and weak C—H...O hydrogen bonds, forming a three-dimensional network. Weak C—H...π inter­actions and π–π stacking inter­actions [centroid–centroid distances = 3.4728 (13) and 3.7339 (13) Å] also occur in the crystal.

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The title compound, C6H6N4S, crystallizes with two independent mol­ecules, A and B, in the asymmetric unit. Both independent mol­ecules are almost planar [maximum deviations of 0.068 (6) Å in mol­ecule A and 0.079 (6) Å in mol­ecule B]. In the crystal, mol­ecules A and B are linked by N—H...S, N—H...N and C—H...S hydrogen bonds, forming a three-dimensional network.

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In the title mol­ecule, C15H20N4OS2, the acetamido fragment is nearly coplanar with the pyridyl ring [C—N—C—C torsion angle = −4.1 (2)°], while the cyclo­hexyl­sulfanyl portion protrudes from this plane [N—C—C—S torsion angle = −40.8 (6)°]. In the crystal, alternating pairwise N—H...O and N—H...N hydrogen bonds across inversion centres form chains along [101], which are associated into stepped layers via offset π–π stacking between pyridyl rings [centroid–centroid distance = 3.566 (1) Å]. The cyclo­hexyl group and the two atoms of the S—C bond attached to it are disordered over two sets of sites with site-occupancy factors of 0.8845 (18) and 0.1155 (18).
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