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In the title mol­ecule, C24H19BrN2O5S, the pyrimidine ring is in a flattened half-chair conformation and the 4-acet­oxy­phenyl group is substituted axially to this ring. The thia­zole ring is essentially planar [with a maximum deviation of 0.012 (2) Å for the N atom] and forms dihedral angles of 17.65 (13) and 88.95 (11)° with the bromo- and acet­oxy-substituted benzene rings, respectively. The dihedral angle between the benzene rings is 81.84 (13) Å. In the crystal, pairs of weak C—H...O hydrogen bonds lead to the formation of inversion dimers. A weak C—H...π inter­action and π–π stacking inter­actions with centroid–centroid distances of 3.5903 (14) Å are observed.
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