organic compounds
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In the title E isomer of the racemic compound, C37H32F2N2O2, the pyridinone ring adopts a twisted half-chair conformation with the N atom deviating by −0.355 (3) Å and with the methylene C atom next to octahydroindolizine moiety deviating by 0.415 (3) Å from the mean plane defined by other four atoms. In the octahydroindolizine system, the pyrrolidine ring exhibits an envelope conformation with the fused methyne C atom deviating by 0.6496 (1) Å from the mean plane defined by four other atoms, and the piperidine ring exhibits a distorted chair conformation as evident from the puckering parameters Q = 0.568 (2) Å, θ = 1.0 (2) and Φ = 256 (11)°. In the crystal, C—HO interactions connect the molecules into chains along [101].
organic compounds
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In the title compound, C39H38N2O4, the pyridinone ring adopts a twisted half-chair conformation with the N atom deviating by 0.3304 (1) and with the methylene C atom adjacent to the octahydroindolizine unit deviating by 0.444 (3) Å from the mean plane defined by the other four atoms. In the octahydroindolizine system, the pyrrolidine ring exhibits an envelope conformation, with the fused methyne C atom deviating by 0.6315 (1) Å from the mean plane defined by the other four atoms, and the piperidine ring exhibits a distorted chair conformation, as reflected in the puckering parameters Q = 0.568 (4) Å, θ = 1.5 (4) and φ = 161 (16)°. In the crystal pairs of weak C—HO interactions form centrosymmetric dimers, which are further connected by C—Hπ interactions. The crystal studied was a non-merohedral twin, with a domain ratio of 0.91:0.09.
organic compounds
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In the title compound, C39H36N2O4S, the piperidine ring adopts a twisted half-chair conformation. In the pyrrolothiazole fused-ring system, the pyrrole ring adopts an envelope conformation (with the C atom bound to the thiazole ring being the flap atom) and the thiazole ring also exhibits an envelope conformation (with the N atom bound to the pyrrole ring as the flap). The molecular structure features a weak intramolecular C—HO interaction. In the crystal, a C—HO interaction forms a linear chain along the diagonal of the ac plane, generating a C(14) graph-set motif. A weak C—Hπ interaction also occurs.
organic compounds
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In the title compound, C30H28N4O, the central pyrrolidine ring adopts an envelope conformation with the CH2 C atom as the flap. The quinoxaline and indene ring systems are planar, with r.m.s. deviations of 0.0165 and 0.0181 Å, respectively. The pyrrolidine ring mean plane forms dihedral angles of 88.84 (1) and 86.14 (1)° with the quinoxaline and indene ring systems, respectively. A weak intramolecular C—HN interaction is observed. In the crystal, C—HO interactions lead to helical supramolecular chains along the b axis having a C(9) motif.
organic compounds
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In the title compound, C31H30N4O, the central pyrrolidine ring adopts an envelope conformation with the methylene C atom being the flap. The quinoxaline and indane rings are each planar, having r.m.s. deviations of 0.030 and 0.050 Å, respectively. The pyrrolidine ring mean plane forms dihedral angles of 88.25 (1) and 83.76 (1)° with the quinoxaline and indane rings, respectively. Intramolecular C—HO and C—HN interactions are observed. In the crystal, C—Hπ interactions lead to helical supramolecular chains along the b-axis direction.
organic compounds
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In the title compound, C27H28N2O3, each of the pyrrolidine rings adopts a twisted conformation, as does the cyclopentane ring. The indane ring has an r.m.s deviation of 0.0693 Å. The dihedral angle between the mean plane of the pyrrolizine ring and indane system is 82.58 (1)°. The piperidine ring has the methyl substituent in an equatorial position and adopts a twisted chair conformation. The molecular structure is stabilized by a weak intramolecular O—HN interaction.
organic compounds
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In the title compound, C18H14N2O5, the pyrrolidine ring adopts a shallow envelope conformation, with the C atom bearing the OH group (and remote from the N atom) displaced by 0.257 (2) Å from the other atoms. The cyclopentane ring has a twisted conformation about the C—C bond bearing one =O and one —OH grouping. The dihedral angle between the five-membered rings (all atoms) is 65.54 (9)° and the OH groups lie to the same side of the ring-junction. The molecular structure features a weak intramolecular O—HO bond and a possible C—Hπ interaction. In the crystal, the molecules are linked into [010] chains by O—HO hydrogen bonds. Weak C—HO bonds connect the chains into (100) sheets.
organic compounds
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In the title compound, C19H16N2O6S, the pyrrolidine ring adopts a twisted conformation with puckering parameters q2 = 0.088 (3) Å and Φ2 = 61.5 (14)°. The cyclopentane ring adopts a twisted conformation with puckering parameters q2 = 0.099 (2) Å and Φ2 = 242.8 (14)°. A weak intramolecular O—HO interaction occurs. In the crystal, pairs of C—HO interactions generate dimers with graph-set motif R22(24) and they are interconnected by pairs of O—HO hydrogen bonds, which link the molecules into inversion dimers with graph-set motif R22(10).