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In the title E isomer of the racemic compound, C37H32F2N2O2, the pyridinone ring adopts a twisted half-chair conformation with the N atom deviating by −0.355 (3) Å and with the methyl­ene C atom next to octa­hydro­indolizine moiety deviating by 0.415 (3) Å from the mean plane defined by other four atoms. In the octa­hydro­indolizine system, the pyrrolidine ring exhibits an envelope conformation with the fused methyne C atom deviating by 0.6496 (1) Å from the mean plane defined by four other atoms, and the piperidine ring exhibits a distorted chair conformation as evident from the puckering parameters Q = 0.568 (2) Å, θ = 1.0 (2) and Φ = 256 (11)°. In the crystal, C—H...O inter­actions connect the mol­ecules into chains along [101].

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In the title compound, C39H38N2O4, the pyridinone ring adopts a twisted half-chair conformation with the N atom deviating by 0.3304 (1) and with the methyl­ene C atom adjacent to the octa­hydro­indolizine unit deviating by 0.444 (3) Å from the mean plane defined by the other four atoms. In the octa­hydro­indolizine system, the pyrrolidine ring exhibits an envelope conformation, with the fused methyne C atom deviating by 0.6315 (1) Å from the mean plane defined by the other four atoms, and the piperidine ring exhibits a distorted chair conformation, as reflected in the puckering parameters Q = 0.568 (4) Å, θ = 1.5 (4) and φ = 161 (16)°. In the crystal pairs of weak C—H...O inter­actions form centrosymmetric dimers, which are further connected by C—H...π inter­actions. The crystal studied was a non-merohedral twin, with a domain ratio of 0.91:0.09.

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In the title compound, C39H36N2O4S, the piperidine ring adopts a twisted half-chair conformation. In the pyrrolo­thia­zole fused-ring system, the pyrrole ring adopts an envelope conformation (with the C atom bound to the thia­zole ring being the flap atom) and the thia­zole ring also exhibits an envelope conformation (with the N atom bound to the pyrrole ring as the flap). The mol­ecular structure features a weak intra­molecular C—H...O inter­action. In the crystal, a C—H...O inter­action forms a linear chain along the diagonal of the ac plane, generating a C(14) graph-set motif. A weak C—H...π inter­action also occurs.

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In the title compound, C30H28N4O, the central pyrrolidine ring adopts an envelope conformation with the CH2 C atom as the flap. The quinoxaline and indene ring systems are planar, with r.m.s. deviations of 0.0165 and 0.0181 Å, respectively. The pyrrolidine ring mean plane forms dihedral angles of 88.84 (1) and 86.14 (1)° with the quinoxaline and indene ring systems, respectively. A weak intra­molecular C—H...N inter­action is observed. In the crystal, C—H...O inter­actions lead to helical supra­molecular chains along the b axis having a C(9) motif.

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In the title compound, C31H30N4O, the central pyrrolidine ring adopts an envelope conformation with the methyl­ene C atom being the flap. The quinoxaline and indane rings are each planar, having r.m.s. deviations of 0.030 and 0.050 Å, respectively. The pyrrolidine ring mean plane forms dihedral angles of 88.25 (1) and 83.76 (1)° with the quinoxaline and indane rings, respectively. Intra­molecular C—H...O and C—H...N inter­actions are observed. In the crystal, C—H...π inter­actions lead to helical supra­molecular chains along the b-axis direction.

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In the title compound, C27H28N2O3, each of the pyrrolidine rings adopts a twisted conformation, as does the cyclo­pentane ring. The indane ring has an r.m.s deviation of 0.0693 Å. The dihedral angle between the mean plane of the pyrrolizine ring and indane system is 82.58 (1)°. The piperidine ring has the methyl substituent in an equatorial position and adopts a twisted chair conformation. The mol­ecular structure is stabilized by a weak intra­molecular O—H...N inter­action.

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In the title compound, C18H14N2O5, the pyrrolidine ring adopts a shallow envelope conformation, with the C atom bearing the OH group (and remote from the N atom) displaced by 0.257 (2) Å from the other atoms. The cyclo­pentane ring has a twisted conformation about the C—C bond bearing one =O and one —OH grouping. The dihedral angle between the five-membered rings (all atoms) is 65.54 (9)° and the OH groups lie to the same side of the ring-junction. The mol­ecular structure features a weak intra­molecular O—H...O bond and a possible C—H...π inter­action. In the crystal, the mol­ecules are linked into [010] chains by O—H...O hydrogen bonds. Weak C—H...O bonds connect the chains into (100) sheets.

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In the title compound, C19H16N2O6S, the pyrrolidine ring adopts a twisted conformation with puckering parameters q2 = 0.088 (3) Å and Φ2 = 61.5 (14)°. The cyclo­pentane ring adopts a twisted conformation with puckering parameters q2 = 0.099 (2) Å and Φ2 = 242.8 (14)°. A weak intra­molecular O—H...O inter­action occurs. In the crystal, pairs of C—H...O inter­actions generate dimers with graph-set motif R22(24) and they are interconnected by pairs of O—H...O hydrogen bonds, which link the mol­ecules into inversion dimers with graph-set motif R22(10).
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